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Topic of blood brain
barrier and CSF circulation
will be explored through
the structure and
function of the
blood brain barrier,
including its
cellular components
and mechanisms of
selective permeability.
We will examine how the
blood brain barrier protects
neural tissue and its role
in neurological diseases,
as well as the production
and circulation of
cerebrospinal fluid and its
importance for brain health.
Finally, the interaction between
the blood brain barrier and
cerebrospinal fluid
will be discussed,
highlighting their joint
roles in maintaining
neural homeostasis and the
consequences of dysfunction.
The blood brain
barrier or BBB is
an essential structure
that maintains
the brain's protected and
stable internal environment,
formed by specialized
endothelial cells
with tight junctions.
It prevents most substances
from passing from the
bloodstream into the brain.
Parasites and astrocyte end
feet further reinforce
this barrier,
creating the neurovascular unit.
The BBB is a dynamic interface,
selectively allowing
vital nutrients
in while blocking toxins,
pathogens, and
harmful fluctuations.
The blood brain barrier's
selective permeability
arises from tight junctions
and specific transport systems.
Only certain molecules
like glucose and
amino acids cross via
specialized transporters
such as Glut one.
Small lipid soluble molecules
may diffuse passively,
but most larger or
hydrophilic substances
