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1. Introduction
2. Lecture structure
3. Basic facts about Alzheimer's disease
4. The complexities of AD genetics
5. Status of genetic association studies in AD
6. The AlzGene database
7. Top AlzGene results: significant by meta-analysis
8. How real are the top results?
9. Grading of epidemiologic credibility
10. Applying the HuGENet guidelines to AlzGene
11. Database for Parkinson's, schizophrenia and AD
12. Current status of genetic studies
13. Top genes for AD
14. Four AlzGene's show association in AD families
15. Variants in TF and ACE affect CSF A-beta levels
16. The four AlzGene's are in the top results
17. Candidate gene vs. GWAS studies
18. Genome-wide association results in AD
19. Three genes on the upper part of the list
20. AlzGene meta-analysis for CLU (APOJ)
21. AlzGene meta-analysis for CR1
22. AlzGene meta-analysis for PICALM
23. APOE (apolipoprotein E)
24. CLU (clusterin [apolipoprotein J])
25. GAB2 (GRB2-associated binding protein 2)
26. ACE (angiotensin converting enzyme)
27. CHRNB2 (beta2-cholinergic receptor, nicotinic)
28. Summary: the complexities of AD genetics
29. Outlook: what's next in AD genetics?
30. Ultra high-throughput genetics technologies
31. Applications of next-generation technologies
32. Thirty years of Alzheimer's genetics - summary (1)
33. Thirty years of Alzheimer's genetics - summary (2)
34. Thirty years of Alzheimer's genetics - summary (3)
35. Acknowledgements

Topics Covered

• Alzheimer's Disease
• Association studies in Alzheimer's Disease
• Systematic meta-analyses and risk loci
• Genome-wide association studies (GWAS)
• Potential functional relevance
• Next generation sequencing in Alzheimer's Disease

Links

Series:

• Alzheimer's Disease

Categories:

• Clinical Practice
• Genetics & Epigenetics
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Bertram, L. (2010, August 26). Thirty years of Alzheimer's genetics: what's new and what's next? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/PJEP4862.
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Publication History

• Published on August 26, 2010

Financial Disclosures

• Dr. Lars Bertram has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.