• Cellular Mechanisms of Mitochondrial Biogenesis in Health
• 23 min
  1. Nuclear control of electron transport chain gene expression

  • Dr. Glenn C. Rowe
• 48 min
  2. Regulation of mitochondrial biogenesis by transcriptional coactivators and estrogen-related receptor alpha

  • Dr. Anastasia Kralli
• 17 min
  3. Protein import into mitochondria

  • Dr. Trevor Lithgow
• 39 min
  4. Mitochondrial phospholipid synthesis and incorporation

  • Prof. Grant Hatch
• 23 min
  5. Mitochondrial DNA replication and transcription

  • Prof. Julio Montoya
• 37 min
  6. Mitochondrial production of reactive oxygen species 1

  • Prof. Martin Brand
• 22 min
  7. Mitochondrial production of reactive oxygen species 2

  • Prof. Martin Brand
• 35 min
  8. Mitophagy - the degradation of dysfunctional organelles

  • Dr. Anna Vainshtein
• Mitochondrial Biogenesis in Physiological Conditions
• 21 min
  9. Thyroid hormone and mitochondrial biogenesis

  • Dr. Joachim Weitzel
• 28 min
  10. Exercise-induced mitochondrial biogenesis in muscle 1

  • Prof. David Hood
• 37 min
  11. Exercise-induced mitochondrial biogenesis in muscle 2

  • Prof. David Hood
• Mitochondrial Biogenesis in Aging and Disease
• 33 min
  12. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 59 min
  13. Exercise and nutrition in mitochondrial disorders

  • Prof. Mark Tarnopolsky
• 42 min
  14. Mitochondrial disorders and neurodegeneration

  • Dr. Jan-Willem Taanman
• 33 min
  15. Reprogramming oxidative phosphorylation in cancer

  • Prof. José Cuezva
• 44 min
  16. Possible roles of mitochondrial biogenesis in aging

  • Dr. Aubrey de Grey
• 31 min
  17. Mitochondria in reproduction and fertility: mitochondria and gametes 1

  • Prof. Pascale May Panloup
• 30 min
  18. Mitochondria in reproduction and fertility: mitochondria and embryo 2

  • Prof. Pascale May Panloup
• 35 min
  19. Mitochondrial morphology and ultrastructure in skeletal muscle

  • Prof. Martin Picard
• 19 min
  20. Improving mitochondrial phenotypes with pharmaceuticals

  • Prof. Christopher Perry
• Mitochondria, Cell Signaling and Apoptosis
• 42 min
  21. Mitochondrial permeability transition

  • Prof. John Lemasters
• 47 min
  22. Pathways of apoptosis in muscle 1

  • Prof. Stephen E. Alway
• 42 min
  23. Pathways of apoptosis in muscle 2

  • Prof. Stephen E. Alway
• 21 min
  24. Controlling mitochondrial reactive oxygen species production for cell signaling 1

  • Dr. Ryan J. Mailloux
• 32 min
  25. Controlling mitochondrial reactive oxygen species production for cell signaling 2

  • Dr. Ryan J. Mailloux
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  26. Reactive oxygen species and myocardial apoptosis

  • Dr. Zhi-Qing Zhao
• 34 min
  27. Mitochondrial biogenesis as a result of exercise

  • Dr. Darrell Neufer
• 30 min
  28. Mechanisms of mitochondrial fusion and fission

  • Dr. Luca Scorrano
• 30 min
  29. Mitochondrial heterogeneity in cells

  • Dr. Tony Collins
• 40 min
  30. Mitochondrial diseases: an update

  • Prof. Salvatore DiMauro
• 41 min
  31. Calcium signaling and mitochondrial function

  • Prof. David Nicholls
• 35 min
  32. Mitochondrial biogenesis during gametogenesis and embryonic development

  • Prof. Pascal Reynier
• 33 min
  33. Mitochondrial complex assembly

  • Dr. Leo Nijtmans
• 33 min
  34. Evolutionary and developmental variation in muscle mitochondrial content

  • Prof. Christopher Moyes
• 33 min
  35. Muscle mitochondrial function and biogenesis with aging

  • Dr. Russell Hepple
• 23 min
  36. The mitochondrial pathway in apoptosis

  • Prof. Douglas Green
• 40 min
  37. Nuclear control of respiratory chain expression by transcriptional activators and coactivators

  • Prof. Richard Scarpulla
• 38 min
  38. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 43 min
  39. Respiration, reactive oxygen species and uncoupling proteins

  • Prof. Martin Brand

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Mitochondrial heterogeneity in cells
3. Mitochondrial function
4. Multiple levels of heterogeneity
5. Sub-cellular heterogeneity
6. Membrane potential - JC1
7. Membrane potential - TMRE
8. Imaging the permeability transition pore
9. Subcellular heterogeneity in PTP
10. Calcium: a ubiquitous messenger
11. Mitochondrial calcium handling
12. Measuring mitochondrial calcium in live cells
13. Agonist evoked calcium signals
14. Graded mitochondrial response
15. Calcium uptake by mitochondria
16. Functionality summary
17. Morphology confusion
18. Fission and fusion
19. How many mitochondria?
20. Luminal continuity
21. Electrical continuity
22. Mitochondria continuity assays
23. 3D reconstructions of mitochondria in live cells
24. Fluorescence recovery after photobleaching
25. DsRed1 mobility
26. DsRed and TMRE
27. Irradiation induced depolarisation
28. Hepatocyte electrical discontinuity
29. HeLa cell discontinuity
30. HeLa cell map
31. Pancreatic acinar and HUVEC maps
32. Cardiac myocyte electrical discontiuity
33. Oxidative damage
34. Electrical discontinuity summary
35. Atypical networks - electrical discontinuity
36. Atypical networks - FRAP
37. Atypical networks summary
38. Final summary
39. Acknowledgement
40. Selected references

Topics Covered

• Levels of mitochondrial heterogeneity
• Subcellular heterogeneity
• Membrane potential
• Permeability transition
• Calcium uptake
• Morphology: network or discrete?
• Live cell mitochondrial 3D reconstruction
• Fluorescence Recovery After Photobleaching (FRAP)
• Electrical continuity
• Atypical networks

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Tony Collins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.