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- Cellular Mechanisms of Mitochondrial Biogenesis in Health
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23 min
1. Nuclear control of electron transport chain gene expression- Dr. Glenn C. Rowe
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48 min
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17 min
3. Protein import into mitochondria- Dr. Trevor Lithgow
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39 min
4. Mitochondrial phospholipid synthesis and incorporation- Prof. Grant Hatch
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23 min
5. Mitochondrial DNA replication and transcription- Prof. Julio Montoya
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37 min
6. Mitochondrial production of reactive oxygen species 1- Prof. Martin Brand
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22 min
7. Mitochondrial production of reactive oxygen species 2- Prof. Martin Brand
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35 min
8. Mitophagy - the degradation of dysfunctional organelles- Dr. Anna Vainshtein
- Mitochondrial Biogenesis in Physiological Conditions
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21 min
9. Thyroid hormone and mitochondrial biogenesis- Dr. Joachim Weitzel
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28 min
10. Exercise-induced mitochondrial biogenesis in muscle 1- Prof. David Hood
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37 min
11. Exercise-induced mitochondrial biogenesis in muscle 2- Prof. David Hood
- Mitochondrial Biogenesis in Aging and Disease
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33 min
12. Mitochondrial diseases: an update- Dr. Ayesha Saleem
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59 min
13. Exercise and nutrition in mitochondrial disorders- Prof. Mark Tarnopolsky
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42 min
14. Mitochondrial disorders and neurodegeneration- Dr. Jan-Willem Taanman
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33 min
15. Reprogramming oxidative phosphorylation in cancer- Prof. José Cuezva
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44 min
16. Possible roles of mitochondrial biogenesis in aging- Dr. Aubrey de Grey
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31 min
17. Mitochondria in reproduction and fertility: mitochondria and gametes 1- Prof. Pascale May Panloup
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30 min
18. Mitochondria in reproduction and fertility: mitochondria and embryo 2- Prof. Pascale May Panloup
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35 min
19. Mitochondrial morphology and ultrastructure in skeletal muscle- Prof. Martin Picard
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19 min
20. Improving mitochondrial phenotypes with pharmaceuticals- Prof. Christopher Perry
- Mitochondria, Cell Signaling and Apoptosis
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42 min
21. Mitochondrial permeability transition- Prof. John Lemasters
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47 min
22. Pathways of apoptosis in muscle 1- Prof. Stephen E. Alway
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42 min
23. Pathways of apoptosis in muscle 2- Prof. Stephen E. Alway
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21 min
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32 min
- Archived Lectures *These may not cover the latest advances in the field
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44 min
26. Reactive oxygen species and myocardial apoptosis- Dr. Zhi-Qing Zhao
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34 min
27. Mitochondrial biogenesis as a result of exercise- Dr. Darrell Neufer
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30 min
28. Mechanisms of mitochondrial fusion and fission- Dr. Luca Scorrano
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30 min
29. Mitochondrial heterogeneity in cells- Dr. Tony Collins
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40 min
30. Mitochondrial diseases: an update- Prof. Salvatore DiMauro
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41 min
31. Calcium signaling and mitochondrial function- Prof. David Nicholls
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35 min
32. Mitochondrial biogenesis during gametogenesis and embryonic development- Prof. Pascal Reynier
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33 min
33. Mitochondrial complex assembly- Dr. Leo Nijtmans
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33 min
34. Evolutionary and developmental variation in muscle mitochondrial content- Prof. Christopher Moyes
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33 min
35. Muscle mitochondrial function and biogenesis with aging- Dr. Russell Hepple
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23 min
36. The mitochondrial pathway in apoptosis- Prof. Douglas Green
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40 min
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38 min
38. Mitochondrial disorders and neurodegeneration- Prof. Anthony Schapira
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43 min
39. Respiration, reactive oxygen species and uncoupling proteins- Prof. Martin Brand
Printable Handouts
Navigable Slide Index
- Introduction
- Overview of the talk
- Mitochondrial structure: ultrastructure (1)
- Mitochondrial structure: ultrastructure (2)
- The mitochondrial organization inside the cell (1)
- Mitochondria are heterogeneous within cells
- Tracking networks within a mitochondrial web
- The mitochondrial organization inside the cell (2)
- Proteins that regulate mitochondrial shape
- Structural features of the dynamin superfamily (1)
- Structural features of the dynamin superfamily (2)
- Three-dimensional reconstruction of dynamin
- Proteins in mitochondrial fusion in S.cerevisiae
- Proteins in mitochondrial fission in S.cerevisiae
- Mitochondrial fusion and fission in yeast
- Mammalian mitochondria-shaping proteins
- Drp1 is required for mitochondrial division
- hFis1 is a component of mitochonrial fission
- hFis1 regulates fission by interaction with DLP1
- Mfn1 and Mfn2 regulate mitochondrial fusion
- OPA1 requires Mfn1 to promote fusion
- How do fusion and fission work?
- Mechanisms of mitochondrial fusion and fission
- Mitochondrial morphology effect on cell functions
- Organization of human mitochondrial DNA
- Mitochondria and apoptosis
- Cytochrome c release during apoptosis
- Remodelling of mitochondrial cristae in apoptosis
- Class II mitochondrion
- A tomogram of a remodelled mitochondrion
- How is cristae remodelling controlled?
- OPA1 independently controls cristae remodelling
- PARL controls cytochrome c release in apoptosis
- The role of DRP1 in apoptosis
- ER BIK initiates cristae remodelling in apoptosis
- Conclusions
Topics Covered
- Mitochondrial ultrastructure
- Mitochondrial organization in the cytosol
- Mitochondria-shaping proteins
- Dynamins and the dynamin superfamily
- Control of mitochondrial shape in yeast
- Control of mitochondrial morphology in mammals
- Mitochondrial fusion and the transmission of mitochondrial DNA
- Changes in mitochondrial ultrastructure during apoptosis
- Mitochondrial fragmentation during apoptosis
- Cristae remodeling and OPA1
Talk Citation
Scorrano, L. (2007, October 1). Mechanisms of mitochondrial fusion and fission [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 11, 2025, from https://doi.org/10.69645/PHOS5018.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Luca Scorrano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
