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1. Introduction
2. Overview of the talk
3. Mitochondrial structure: ultrastructure (1)
4. Mitochondrial structure: ultrastructure (2)
5. The mitochondrial organization inside the cell (1)
6. Mitochondria are heterogeneous within cells
7. Tracking networks within a mitochondrial web
8. The mitochondrial organization inside the cell (2)
9. Proteins that regulate mitochondrial shape
10. Structural features of the dynamin superfamily (1)
11. Structural features of the dynamin superfamily (2)
12. Three-dimensional reconstruction of dynamin
13. Proteins in mitochondrial fusion in S.cerevisiae
14. Proteins in mitochondrial fission in S.cerevisiae
15. Mitochondrial fusion and fission in yeast
16. Mammalian mitochondria-shaping proteins
17. Drp1 is required for mitochondrial division
18. hFis1 is a component of mitochonrial fission
19. hFis1 regulates fission by interaction with DLP1
20. Mfn1 and Mfn2 regulate mitochondrial fusion
21. OPA1 requires Mfn1 to promote fusion
22. How do fusion and fission work?
23. Mechanisms of mitochondrial fusion and fission
24. Mitochondrial morphology effect on cell functions
25. Organization of human mitochondrial DNA
26. Mitochondria and apoptosis
27. Cytochrome c release during apoptosis
28. Remodelling of mitochondrial cristae in apoptosis
29. Class II mitochondrion
30. A tomogram of a remodelled mitochondrion
31. How is cristae remodelling controlled?
32. OPA1 independently controls cristae remodelling
33. PARL controls cytochrome c release in apoptosis
34. The role of DRP1 in apoptosis
35. ER BIK initiates cristae remodelling in apoptosis
36. Conclusions

Topics Covered

• Mitochondrial ultrastructure
• Mitochondrial organization in the cytosol
• Mitochondria-shaping proteins
• Dynamins and the dynamin superfamily
• Control of mitochondrial shape in yeast
• Control of mitochondrial morphology in mammals
• Mitochondrial fusion and the transmission of mitochondrial DNA
• Changes in mitochondrial ultrastructure during apoptosis
• Mitochondrial fragmentation during apoptosis
• Cristae remodeling and OPA1

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Cell Biology

Talk Citation

Scorrano, L. (2007, October 1). Mechanisms of mitochondrial fusion and fission [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/PHOS5018.
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Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Luca Scorrano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.