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1. Introduction
2. The immediate problem of childhood pain
3. The longer term impact of childhood pain
4. How can pain be measured in human infants?
5. EMG analysis of spinal nociceptive reflexes
6. Cortical pain responses in infants using NIRS
7. Cortical pain potentials using EEG
8. Animal models for human pain development
9. Increased nociceptive reflexes in young animals
10. Increased nociceptive activity in human infants
11. Lack of spatial precision in young animals
12. Lack of spatial precision in human infants
13. Dorsal horn neurons in young animals
14. The drivers of dorsal horn neuronal maturation
15. The organisation of nociceptive circuits
16. Activity dependence of nociceptive circuitry
17. Inhibition in the development of nociceptive circuits
18. Inhibitory and excitatory dorsal horn neurons
19. Connections from brainstem to spinal cord
20. Polarity of tonic brainstem control of nociception
21. RVM stimulation causes nociception switch
22. What we have shown so far
23. Persistent pain and immature pain circuits
24. Tissue damage in neonatal intensive care
25. Effect of inflammation and tissue damage
26. Central sensitization in human infants
27. Development of neuropathic pain
28. The neuroimmune response
29. Long term effect of early pain experience
30. Early skin wounds cause skin sensitivity changes
31. Pain memory
32. Blocking peripheral neural activity reverses effect
33. Early injury can cause generalised hyposensitivity
34. Lasting sensory effect of early pain in man
35. Early pain experience and sensory processing
36. Summary
37. Acknowledgements

Topics Covered

• The immediate problem of childhood pain
• The long term impact of childhood pain
• How can pain be measured in infants?
• Cortical pain responses
• Nociceptive reflexes
• What drives the 'tuning' or maturation of dorsal horn neuronal properties and nociceptive reflexes?
• Can immature pain circuits respond to persistent injury or inflammation?
• Tissue damage and inflammation
• Central sensitization
• Neuropathic pain development
• Does early pain experience shape adult pain perception?
• Pain memory

Links

Series:

• Pain and the Control of Pain

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on February 25, 2010

Financial Disclosures

• Prof. Maria Fitzgerald has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.