• Clinical Introduction
• 49 min
  1. Frontotemporal dementia

  • Prof. Bruce Miller
• 40 min
  2. Huntington's disease

  • Prof. Roger Barker
• Neuroimaging
• 22 min
  3. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• Pathology, Genetic and Molecular Aspects (1)
• 21 min
  4. Neurodegenerative disease: expression levels of normal sequence pathogenic proteins contribute to risk of disease

  • Prof. John Hardy
• 42 min
  5. A molecular understanding of Alzheimer's disease

  • Prof. John Hardy
• 33 min
  6. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 52 min
  7. The role of MAPT (Tau) in neurodegenerative disease: one bullet with many triggers

  • Dr. Michael Hutton
• Pathology, Genetic and Molecular Aspects (2)
• 46 min
  8. The molecular biology of Huntington's disease

  • Prof. David C. Rubinsztein
• 46 min
  9. Metals, oxidative stress and neurodegeneration

  • Prof. Ashley Bush
• Latest Developments in the Field
• 46 min
  10. Animal models of tauopathy

  • Prof. David Westaway
• 61 min
  11. Parkinson's disease and transplants

  • Prof. Roger Barker
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  12. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 36 min
  13. Motor neurone disease: molecular basis

  • Prof. Kevin Talbot
• 51 min
  14. Alzheimer's disease (AD)

  • Prof. John Hodges
• 53 min
  15. Frontotemporal dementia syndromes

  • Prof. John Hodges
• 38 min
  16. Motor neurone disease: clinical aspects

  • Prof. Kevin Talbot
• 26 min
  17. Neuro-imaging in dementia: using MRI in routine work-up

  • Prof. Philip Scheltens
• 53 min
  18. Prion diseases

  • Prof. Pierluigi Gambetti
• 38 min
  19. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 44 min
  20. Mutations in parkinsonian syndromes

  • Dr. Andrew Singleton
• 42 min
  21. Experimental therapies in Alzheimer's disease: the development and use of mouse models

  • Prof. David Westaway
• 32 min
  22. Frontotemporal dementia

  • Prof. Bruce Miller
• 57 min
  23. Parkinson disease

  • Prof. Stanley Fahn
• 12 min
  24. Ubiquitination and Alzheimer related disorders

  • Prof. John Mayer
• 35 min
  25. Atypical parkinsonian syndromes

  • Dr. David Burn

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Overview
3. Prevalence
4. Neary criteria
5. Variants of FTD
6. Tau positive and tau negative variants
7. Tau immunopositive inclusions
8. Inclusions in sporadic ALS
9. Is FTD genetic?
10. Progranulin a new FTD gene
11. Progranulin haploinsufficiency
12. VBM analysis of FTLD with progranulin mutations
13. Progranulin gene structure
14. Progranulin highly expressed in peripheral blood
15. The syndrome
16. The region
17. The circuit
18. Cells, molecules and genes
19. FTD atrophy by clinical stage
20. Von Economo neuron (VENs) ACC and FI
21. VENs
22. Vens: vulnerable neuron in FTD?
23. Regions unique to individual behaviors
24. Overeating in FTD
25. Evolution of the "self"
26. Development of self - mirror studies
27. Development of self
28. Startle in FTD
29. Traditional frontal neuropsychology
30. Amyloid imaging
31. Research criteria for FTD
32. Conclusions
33. Acknowledgements

Topics Covered

• Prevalence and nomenclature of FTD
• The pathology of FTD (tau, TDP-43)
• The genetics of FTD (tau, progranulin)
• Patterns of atrophy and neuroanatomical correlates of behavior and cognition
• von Economo neurons
• Neuroimaging (amyloid imaging)
• Treatment

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on February 14, 2010
• Archived on January 31, 2022

Financial Disclosures

• Prof. Bruce Miller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.