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Printable Handouts
Navigable Slide Index
- Introduction
- Genetic association studies (1)
- Genetic association studies (2)
- Linkage vs. association (1)
- Linkage vs. association (2)
- Common variants for common diseases?
- Genealogy at causal locus (haploid)
- What if the causal locus isn't genotyped?
- LD from shared founder haplotype
- Strength of LD marker
- Genetic heterogeneity
- Genotypes at SNPs in strong LD
- Quality Control (QC)
- Hardy-Weinberg equilibrium
- Principal component analysis (PCA)
- Single SNP tests of association (general model)
- Single SNP tests of association (1-df tests)
- Armitage trend test
- Logistic regression
- Quantitative traits: linear regression
- Bayesian analyses
- Multiple testing
- Multipoint SNP analyses
- Haplotype-based analyses
- Inferring phase
- Problems with haplotype analyses
- Haplotype space
- Imputation
- Confounding in genetic association studies
- Population structure
- P-P plot vs. GC-adjusted P-P plot
- Family-based tests of linkage and association
- Software
- References
Topics Covered
- Linkage vs. association
- Common variants for common diseases
- Genealogy
- Linkage disequilibrium
- Founder haplotypes
- Genetic heterogeneity
- Hardy Weinberg equilibrium
- Principal component analysis
- Single SNP tests of association for case-control data
- Armitage trend test
- Logistic regression
- Quantitative traits
- Bayesian analyses
- Multiple testing
- Haplotype-based analyses
- Inferring phase
- Problems with haplotype analyses
- Imputation
- Genetic association studies
- Family-based tests of linkage and association
- Software
Talk Citation
Balding, D. (2009, December 28). Genetic association studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 16, 2024, from https://doi.org/10.69645/HTCV2081.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Balding has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.