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Printable Handouts
Navigable Slide Index
- Introduction
- Tuberculosis (TB) today
- TB and HIV epidemic in South Africa
- XDR-TB in Tugela Ferry
- Patients co-infected with TB and HIV in rural SA
- Susceptibility pattern of isolates from Tugela Ferry
- Tugela Ferry
- Hospital acquired XDR-TB (1)
- Hospital acquired XDR-TB (2)
- XDR-TB realities
- XDR-TB spread in KwaZulu-Natal 2005-2007
- TB sanatorium evolution
- The war on XDR-TB - clinical needs
- M. tuberculosis knowledge - 1985 (1)
- Why is knowledge important?
- The causes for TB - 1847
- Causes of consumption - therapy
- Edward Livingston Trudeau (1)
- Edward Livingston Trudeau (2)
- Jean Antoine Villemin
- Gerhard Armauer Hansen
- Koch's postulate
- M. tuberculosis knowledge - 1985 (2)
- Molecular Koch's postulate
- First fulfillment of molecular Koch's postulate
- Why no genetics for M. tuberculosis?
- Leprosy
- Mycobacteriophage delivery vectors (1)
- Mycobacteriophage delivery vectors (2)
- fadD knockout strains
- Genetics = new knowledge
- Bacille Calmette and Guerin (BCG)
- Why is BCG attenuated?
- Molecular Koch's postulate: application to BCG
- Reconstruction of BCG
- The loss of RD1 attenuates MTB
- Primary attenuation of BCG
- Mechanism of action of INH and ETH in M. tb
- How tuberculosis may develop drug resistance
- InhA is the target of INH and ETH
- Common target of Isoniazid and Ethionamide
- Conclusions
Topics Covered
- Tuberculosis today
- Susceptibility pattern
- Hospital acquired XDR-TB
- XDR-TB realities
- TB sanatorium evolution
- Development of knowledge of TB
- Causes of consumption: Samuel Sheldon Fitch and Edward Livingston Trudeau
- Molecular Koch's postulate
- Why no genetics for M. tuberculosis?
- Mycobacteriophage delivery vectors
- Genetics = new knowledge
- Bacille Calmette and Guerin (BCG)
- Reconstruction of BCG
- Primary attenuation of BCG
- By understanding how M. Tuberculosis evades immunity it should be possible to make better vaccines than BCG
Links
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Talk Citation
Jacobs, W. (2009, November 24). The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/ITJA2085.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. William Jacobs has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition
Published on November 24, 2009
42 min
A selection of talks on Infectious Diseases
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