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1. Introduction
2. Tuberculosis (TB) today
3. TB and HIV epidemic in South Africa
4. XDR-TB in Tugela Ferry
5. Patients co-infected with TB and HIV in rural SA
6. Susceptibility pattern of isolates from Tugela Ferry
7. Tugela Ferry
8. Hospital acquired XDR-TB (1)
9. Hospital acquired XDR-TB (2)
10. XDR-TB realities
11. XDR-TB spread in KwaZulu-Natal 2005-2007
12. TB sanatorium evolution
13. The war on XDR-TB - clinical needs
14. M. tuberculosis knowledge - 1985 (1)
15. Why is knowledge important?
16. The causes for TB - 1847
17. Causes of consumption - therapy
18. Edward Livingston Trudeau (1)
19. Edward Livingston Trudeau (2)
20. Jean Antoine Villemin
21. Gerhard Armauer Hansen
22. Koch's postulate
23. M. tuberculosis knowledge - 1985 (2)
24. Molecular Koch's postulate
25. First fulfillment of molecular Koch's postulate
26. Why no genetics for M. tuberculosis?
27. Leprosy
28. Mycobacteriophage delivery vectors (1)
29. Mycobacteriophage delivery vectors (2)
30. fadD knockout strains
31. Genetics = new knowledge
32. Bacille Calmette and Guerin (BCG)
33. Why is BCG attenuated?
34. Molecular Koch's postulate: application to BCG
35. Reconstruction of BCG
36. The loss of RD1 attenuates MTB
37. Primary attenuation of BCG
38. Mechanism of action of INH and ETH in M. tb
39. How tuberculosis may develop drug resistance
40. InhA is the target of INH and ETH
41. Common target of Isoniazid and Ethionamide
42. Conclusions

Topics Covered

• Tuberculosis today
• Susceptibility pattern
• Hospital acquired XDR-TB
• XDR-TB realities
• TB sanatorium evolution
• Development of knowledge of TB
• Causes of consumption: Samuel Sheldon Fitch and Edward Livingston Trudeau
• Molecular Koch's postulate
• Why no genetics for M. tuberculosis?
• Mycobacteriophage delivery vectors
• Genetics = new knowledge
• Bacille Calmette and Guerin (BCG)
• Reconstruction of BCG
• Primary attenuation of BCG
• By understanding how M. Tuberculosis evades immunity it should be possible to make better vaccines than BCG

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Jacobs, W. (2009, November 24). The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2023, from https://hstalks.com/bs/1478/.
Export Citation (RIS)

Publication History

• Published on November 24, 2009

Financial Disclosures

• Prof. William Jacobs has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.