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We hope you have enjoyed this limited-length demo
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- View the Talks
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1. The pre-analytical phase of laboratory medicine
- Prof. Giuseppe Lippi
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2. Fundamentals of complete blood count analysis- Prof. Roberta Rolla
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3. Laboratory assessment of coagulation- Prof. Gian Luca Salvagno
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4. Oncological biomarkers
- Prof. Dr. Tomris Ozben
-
5. Liquid biopsy
- Dr. Fabio Del Ben
-
6. Clinical biochemistry: introduction
- Dr. Anna Carobene
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Speaker disclosures
- How to diagnose cancer?
- Tumor markers in the current and future clinical practice
- Practical advantages of tumor marker measurements
- Methods for tumor markers
- Methods for detection
- What are the advantages of immunoassay tests?
- Liquid biopsy assays
- Evaluation of tumor markers
- Criteria for an ideal tumor marker
- Some key points
- Requirements for tumor marker assays
- International Standards (IS) & Reference Preparations (IRP)
- α-Fetoprotein (AFP)
- Cancer antigen CA19-9
- Factors causing false negative results in serum levels of TMs
- Some benign conditions associated with rise in tumor markers
- Improvement of diagnostic performance
- Improvement of diagnostic performance with TM kinetics
- Combining tumor markers for improving diagnostic performance
- Clinical uses of tumor markers
- Current uses of tumor markers
- Screening of asymptomatic individuals
- Determination of risk
- Validated tumor markers for screening
- TMs in screening asymptomatic subjects for cancer
- Prostate cancer screening
- Diagnosis of cancers based on tumor markers only (1)
- Diagnosis of cancers based on tumor markers only (2)
- Differential diagnosis
- Use of tumor markers in prognosis
- Staging/prognosis
- Therapy-predictive markers in cancer
- Different responses of the patients
- Tumor heterogeneity
- Surveillance and recurrence monitoring
- Genetic markers
- Therapies based on genetic mutations
- Future directions (1)
- Future directions (2)
- Thank you
Topics Covered
- Tumor markers in the current and future clinical practice
- Methods for tumor marker detection
- International Standards (IS) & Reference Preparations (IRP)
- Combining tumor markers for improving diagnostic performance
- Clinical uses of tumor markers
- Genetic markers
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Ozben, T. (2026, February 26). Oncological biomarkers [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2026, from https://doi.org/10.69645/NBTQ4480.Export Citation (RIS)
Publication History
- Published on February 26, 2026
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Biochemistry
Transcript
Please wait while the transcript is being prepared...
0:00
Hi, everybody.
I am Professor Tomris Ozben from
Akdeniz University,
Medical Faculty,
Department of Clinical
Biochemistry,
and also from the University
of Modena and Reggio Emilia,
Medical Faculty, Clinical
and Experimental
Medicine Ph.D. Program.
0:17
Today, I will talk about
oncological biomarkers,
biomarkers for cancer diagnosis,
progression, and
treatment monitoring.
0:27
I have nothing to disclose.
0:31
Diagnosing cancer at an early
stage is very important,
but it is not easy due
to several reasons,
and also including lack of
symptoms at early stages.
Most diagnostic procedures are
not suitable for early diagnosis
because they can
detect tumors of
at least 1-2 centimeters
in size, or even more.
But the tumor markers
we are using in
daily routine practice
are still considered as
one of the highly
valuable tools for
detection and follow-up
of malignant tumors.
1:05
Before the introduction of
modern imaging techniques
and recent developments
in molecular diagnostics,
tumor markers were commonly used
as diagnostic tools for the
management of cancer patients,
and we are still using
them in our daily routine.
But it is important to choose
the right tumor markers
in the right settings
to optimize patients'
health outcomes
and to keep healthcare
costs reasonable.
1:34
Tumor markers have some
practical advantages,
because they can be
measured in body fluids,
such as blood and urine, and
because they can be obtained
with minimal inconvenience
to the individuals
and their automated
essays are available.
They also provide
quantitative test results
and have objective endpoints.
Tumor markers are relatively
cheap compared to radiological,
histological, and
endoscopic procedures.