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- Principles in Bacterial Pathogenesis
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43 min
1. The molecular basis of bacterial pathogenicity: an overview- Prof. B. Brett Finlay
- Gram Negative Pathogens
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50 min
2. Deciphering shigella invasion of epithelial cells- Prof. Philippe Sansonetti
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43 min
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57 min
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34 min
5. Bordetella pertussis- Prof. Alison Weiss
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37 min
6. Salmonellae: molecular basis of infection- Prof. Samuel Miller
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43 min
7. The diversity of Escherichia coli infections- Prof. Michael Donnenberg
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18 min
8. Bacterial activation of epithelial signaling- Prof. Alice Prince
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48 min
9. Human pathogenic Yersinia species- Prof. James Bliska
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32 min
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46 min
11. Dental pathogens- Prof. Ann Progulske-Fox
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35 min
12. Haemophilus- Prof. Robert Munson
- Gram Positive Pathogens
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53 min
13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model- Prof. Pascale Cossart
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42 min
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48 min
15. Molecular pathogenesis and prevention of Staphylococcus aureus infections- Prof. Olaf Schneewind
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49 min
16. Streptococcus pyogenes disease and molecular pathogenesis- Prof. P. Patrick Cleary
- Host Responses
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29 min
17. Microbial recognition and the immune response- Dr. Dana Philpott
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40 min
18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions- Prof. Vanessa Sperandio
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47 min
19. Toll-like receptor signalling during infection and inflammation- Prof. Luke O'Neill
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56 min
20. The human indigenous microbiota- Prof. David Relman
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53 min
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47 min
22. Role of neutrophils in acute lung injury and repair- Prof. Gregory Downey
- Preventatives and Therapeutics
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35 min
23. Antibiotics and antibiotic resistance- Prof. Gerry Wright
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36 min
24. Vaccines: a health insurance of the 21st century- Prof. Rino Rappuoli
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41 min
25. Biodefense vaccines- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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39 min
26. Vaccines in the modern world- Prof. Gordon Dougan
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39 min
27. Bacterial infection of epithelial signaling- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Oral bacterial diversity
- The major oral diseases
- Caries
- Caries is a "dieto-infectious disease"
- Stephan curve
- The Stephan curve over the course of a day
- Ecological basis for the development of caries
- Requirements for cariogenicity
- Streptococcus mutans
- S. mutans virulence
- The physiology of S. mutans
- Acquisition of S. mutans
- Adherence and accumulation of S. mutans
- P1 (antigen I/II)
- The P1 protein
- Sucrose-dependent adherence
- S. mutans biofilm formation
- Wild-type S. mutans biofilms
- Biofilm warfare
- S. mutans and exo-polysaccharide metabolism
- S. mutans and sucrose
- S. mutans is not the only caries pathogen
- Short summary: caries
- Periodontal diseases
- Periodontitis
- Healthy vs. diseased sites
- Bacteria and periodontal disease
- Pathogenic process
- Periodontopathogens model
- Aggregatibacter actinomycetemcomitans (Aa) (1)
- Aggregatibacter actinomycetemcomitans (Aa) (2)
- Aa adhesins
- Aa fimbriae
- Aa fimbriae - change of colony morphology
- EmaA
- Aa toxins
- Lipopolysaccharide of Aa
- Leukotoxin (LtxA) (1)
- Leukotoxin (LtxA) (2)
- Leukotoxin operon
- Significance of Ltx
- Immunosuppressive factor
- Aa invasion of host cell (1)
- Aa invasion of host cell (2)
- Aa attaches to host cell microvilli
- Aa attachment to host cell
- Aa found in membrane projections of host cell
- TEM of Aa in projection between cells
- Review: Aa virulence mechanisms
- Porphyromonas gingivalis (Pg)
- Pathogenic mechanisms of P. gingivalis
- P. gingivalis adhesins
- P. gingivalis fimbriae (1)
- P. gingivalis fimbriae (2)
- P. gingivalis hemagglutinins
- P. gingivalis hemagglutinin genes
- Attachment of E. coli expressing HagA
- Attachment of E. coli expressing HagB
- P. gingivalis proteinases
- Gingipains (1)
- Gingipain activity and structure
- Gingipain translation products
- Domain structure of gingipains
- Gingipains (2)
- P. gingivalis invasion
- P. gingivalis does not invade all cell types equally
- P. gingivalis invasion of gingival epithelial cells
- Pg and human cardiovascular cells interaction
- Invasion of Pg to humane cardiovascular cells (1)
- Invasion of Pg to humane cardiovascular cells (2)
- Colocalization of Pg in endothelial cells
- Pg trafficking in endothelial cells
- Invasion of Pg to humane cardiovascular cells (3)
- Conclusion - invasion
- Summary: factors that contribute to Pg virulence
- Impact of oral diseases on systemic health
- Cardiovascular and periodontal diseases
- Patients with CVDs have periodontal diseases
- CVDs and periodontal disease: animal studies
- CVDs and periodontal disease: humans (1)
- CVDs and periodontal disease: humans (2)
- CVDs and periodontal disease: humans (3)
- Atherosclerosis - present thinking
- Oral bacteria affect CVS - potential mechanisms
- The significance of bacteremia
- Summary: CVD and periodontal diseases
- Overall summary
- Thank you
- References (1)
- References (2)
Topics Covered
- Mechanisms of dental caries
- Virulence factors of Streptococcus mutans
- Periodontal disease
- Virulence mechanisms of Aggregatibacter actinomycetemcomitans
- Virulence mechanisms of Porphyromonas gingivalis
- Periodontal diseases and cardiovascular diseases
Links
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Talk Citation
Progulske-Fox, A. (2009, October 28). Dental pathogens [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/LHCI9121.Export Citation (RIS)
Publication History
- Published on October 28, 2009
Financial Disclosures
- Prof. Ann Progulske-Fox has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
