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1. Introduction
2. Shigella invasion process
3. Histopathology of shigellosis
4. Functional genomics of S. flexneri
5. The shigellosis disease process
6. Two mechanisms for bacterial penetration
7. pWR100: the virulence plasmid of S. flexneri 5a
8. The Shigella invasion pathogenicity island
9. Assembly of type III protein delivery system
10. IpaB and IpaD: sensor-adaptor at the needle tip
11. Shigella trigger mechanism for cell invasion
12. Signaling in the penetration process
13. Cortactin - second wave of signaling
14. IpaC induces Src autophosphorylation
15. Src is activated early at Shigella entry site
16. Src is necessary for actin foci formation
17. Cortactin silencing blocks the entry process
18. C351 insertion in IpaC effector C-terminal domain
19. IpaC last 72 aa induce actin-foci-like structures
20. IpaC-dependent actin nucleation
21. Shigella motility within and between the cells
22. Actin-dependent intracellular motility of Shigella
23. Shigella intracellular motility - video
24. Entry and cell-to cell spread of Shigella
25. Acknowledgements

Topics Covered

• A genetic and molecular analysis of the mechanisms used by the bacterial pathogen Shigella to invade epithelial cells
• Identification of bacterial effectors of invasion, mode of delivery, nature of cell targets
• How a bacterial pathogen like Shigella causes the rupture and inflammatory destruction of the intestinal epithelial barrier
• How it also regulates the inflammatory response
• The accent is on identification of the bacterial effectors and their cellular targets

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Sansonetti, P. (2009, October 29). Deciphering shigella invasion of epithelial cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2023, from https://hstalks.com/bs/1464/.
Export Citation (RIS)

Publication History

• Published on October 29, 2009

Financial Disclosures

• Prof. Philippe Sansonetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.