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Printable Handouts
Navigable Slide Index
- Introduction
- KIR regulate NK cell activity
- Domain structure of human KIRs
- HLA class I and KIR
- Unique KIR haplotypes that differ in gene content
- Features of KIR
- Stochastic expression of KIR genes
- HLA ligands for KIRs
- HLA-1 and KIR interaction model
- Summary of KIR polymorphism
- KIR disease associations
- Inhibition level of 2DL1,2,3 genotypes
- KIR2DL3 + HLA-C1 homozygosity and HCV
- KIR/HLA-C genotypes and HCV clearance
- HLA-C1, HLA-C2 NK cells and IAV
- KIR2DL3+ NK cells respond faster to influenza
- Roll of NK-cells in successful pregnancy
- Baby's C grp 2 confers strong inhibition of NK cells
- AA frequent among pre-eclamptic mothers
- Activating KIR2DS associate with psoriatic arthritis
- KIR2DS1 and S2 associate with psoriatic arthritis
- Multiplicity of synergistic interactions
- Bifurcation of HLA-B allotypes
- HLA-Bw4 vs. CD4 decline and viral load increase
- Interactions between Bw4 and KIR3DS1
- IR3DS1 + Bw4-80I is protective against AIDS
- NK cell viral inhibition assay
- KIR3DS1 and HLA-B Bw4-80I suppress HIV-1
- Model: KIR3DS1/Bw4-80I protects against HIV
- Inhibitory KIR genotypes and cervical neoplasia
- Balance between activating and inhibitory KIR
- Widespread effects of KIR diversity
- Acknowledgements
Topics Covered
- Introduction to KIR variation and disease association – Distinguishing KIR A and B haplotypes – Effect of KIR haplotype variation on pregnancy outcome – KIR association with risk of cancer and infectious diseases – Contrasting effects of KIR/HLA genotypes on viral infections vs. cancer
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Talk Citation
Carrington, M. (2021, August 31). The influence of variation at the killer cell immunoglobulin-like receptor gene complex on human disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/FIMD3353.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Mary Carrington has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Update Available
The speaker addresses developments since the publication of the original talk. We recommend listening to the associated update as well as the lecture.
- Full lecture Duration: 25:55 min
- Update Duration: 11:31 min
The influence of variation at the killer cell immunoglobulin-like receptor gene complex on human disease
A selection of talks on Cell Biology
Transcript
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0:00
Good afternoon. I'm Mary Carrington and I will present a talk describing the influence of
variation at the killer cell immunoglobulin-like receptor gene complex on human disease.
0:14
Natural killer cells express killer cell immunoglobulin-like receptors or KIR on
their cell surface that can confer either
activating or inhibitory signals to the NK cell.
Inhibitory KIR recognize specific allotypes of HLA class I on potential targets,
and if these ligands are present on a target cell,
the inhibitory KIR will send a signal not to kill that target
because it is normal in terms of HLA class I expression.
Some virally infected cells and some tumor cells down-regulate
HLA class I in order to escape cytotoxic T cell recognition.
In this case, the inhibitory KIR will not see its ligand in the normal context,
and an activating receptor,
which can be an activating KIR,
can now send a signal to kill that target
as it is aberrant in terms of class I expression.
1:13
The nomenclature for the KIR genes and molecules
is based on the number of extracellular domains,
termed 2D or 3D, and whether the molecule has a long or short cytoplasmic tail.
On the far left are three domain long-tailed KIR termed KIR 3DL.
On the far right is a three domain short-tailed KIR termed KIR 3DS.
In general, the long-tailed KIR are inhibitory and the short-tailed KIR are activating.
The genes encoding ligands for KIR are the HLA class I genes which map to the MHC,
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