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1. Introduction
2. Vogelstein-Kinzler model of cancer progression
3. Propagate epithelial cells in distinct culture media
4. The importance of normal cell of origin (CO)
5. CO determine tumor morphology and progression
6. Normal and cancer cells hierarchical organization
7. BPLER more competent to spawn metastases
8. The invasion metastasis cascade (IMC)
9. Two phases of the IMC
10. The last step of the IMC
11. The behavior of a BPLER xenograft in mouse host
12. EMT in BPLER mammary epithelial cells
13. Importance of cancer cells microenvironment
14. EMT is a complex process
15. EMT and embryogenesis
16. EMT in the primitive neural crest
17. Twist transcription factor
18. Transcription factors involved in EMT
19. Cancer cells use EMT for invasion
20. Twist acts pleiotropically to reprogram expression
21. Twist is essential for lung metastases
22. The effect of Twist on different steps of the IMC
23. Twist effects most of the IMC steps
24. Behavior of implanted transformed melanocytes
25. The Slug TF plays a prominent role in emigration
26. Slug enables emigration from primitive neural crest
27. Slug suppression strongly inhibits metastasis
28. The importance of FOXC2
29. FOXC2 expression in human breast cancer
30. FOXC2 associated with basaloid breast cancer (1)
31. FOXC2 associated with basaloid breast cancer (2)
32. The EMT-inducing TF intercommunicate (1)
33. The EMT-inducing TF intercommunicate (2)
34. What is the nature of cells generated by an EMT?
35. FOXC2 expression in normal and EMT cells
36. EMT product might be stem cells
37. Markers for carcinomal MESC
38. The effects of EMT induction on MEC (1)
39. Induction of EMT by Snail and Twist
40. Gene expression of MESC and ME non-SC
41. Stem-like cells express mesenchymal markers
42. Stem-like cells in primary human breast samples
43. Activation of Twist-ER or Snail-ER by tamoxifen
44. EMT and cancer progression
45. Most chemotherapies kill the non-CSCs

Topics Covered

• Vogelstein-Kinzler model of multi-step colon cancer pathogenesis
• Cell of origin determines tumor morphology and behaviour
• Hierarchical organization of normal epithelial tissues
• Similar hierarchical organization of cancer cells in a tumor
• The invasion-metastasis cascade
• Physical dissemination
• Adaptation to and proliferation in a foreign tissue
• Colonization
• Epithelial-mesenchymal transition (EMT)
• The microenvironment of the primary tumor
• Twist transcription factor
• Slug TF
• What is the nature of cells generated by an EMT?
• EMT and cancer progression

Links

Categories:

• Cancer

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on September 13, 2009

Financial Disclosures

• Prof. Robert Weinberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.