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Printable Handouts
Navigable Slide Index
- Introduction
- Vogelstein-Kinzler model of cancer progression
- Propagate epithelial cells in distinct culture media
- The importance of normal cell of origin (CO)
- CO determine tumor morphology and progression
- Normal and cancer cells hierarchical organization
- BPLER more competent to spawn metastases
- The invasion metastasis cascade (IMC)
- Two phases of the IMC
- The last step of the IMC
- The behavior of a BPLER xenograft in mouse host
- EMT in BPLER mammary epithelial cells
- Importance of cancer cells microenvironment
- EMT is a complex process
- EMT and embryogenesis
- EMT in the primitive neural crest
- Twist transcription factor
- Transcription factors involved in EMT
- Cancer cells use EMT for invasion
- Twist acts pleiotropically to reprogram expression
- Twist is essential for lung metastases
- The effect of Twist on different steps of the IMC
- Twist effects most of the IMC steps
- Behavior of implanted transformed melanocytes
- The Slug TF plays a prominent role in emigration
- Slug enables emigration from primitive neural crest
- Slug suppression strongly inhibits metastasis
- The importance of FOXC2
- FOXC2 expression in human breast cancer
- FOXC2 associated with basaloid breast cancer (1)
- FOXC2 associated with basaloid breast cancer (2)
- The EMT-inducing TF intercommunicate (1)
- The EMT-inducing TF intercommunicate (2)
- What is the nature of cells generated by an EMT?
- FOXC2 expression in normal and EMT cells
- EMT product might be stem cells
- Markers for carcinomal MESC
- The effects of EMT induction on MEC (1)
- Induction of EMT by Snail and Twist
- Gene expression of MESC and ME non-SC
- Stem-like cells express mesenchymal markers
- Stem-like cells in primary human breast samples
- Activation of Twist-ER or Snail-ER by tamoxifen
- EMT and cancer progression
- Most chemotherapies kill the non-CSCs
Topics Covered
- Vogelstein-Kinzler model of multi-step colon cancer pathogenesis
- Cell of origin determines tumor morphology and behaviour
- Hierarchical organization of normal epithelial tissues
- Similar hierarchical organization of cancer cells in a tumor
- The invasion-metastasis cascade
- Physical dissemination
- Adaptation to and proliferation in a foreign tissue
- Colonization
- Epithelial-mesenchymal transition (EMT)
- The microenvironment of the primary tumor
- Twist transcription factor
- Slug TF
- What is the nature of cells generated by an EMT?
- EMT and cancer progression
Talk Citation
Weinberg, R. (2024, October 6). Invasion, metastasis and stem cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/WSOC3543.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Robert Weinberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.