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Printable Handouts
Navigable Slide Index
- Introduction
- Core hematology parameters
- Minimizing variability
- Physiological / procedural variability
- Effect of strain
- Effect of excitement / fear
- Effect of restraint stress on leukocytes (rats)
- Effect of collection time on leukocyte counts
- Effect of collection site (mice)
- Artifact
- Other contributors to variability
- Appropriate use of reference intervals
- Some good study design practices
- Purpose of hematology tests
- Predictability for human hematotoxicity >/= 90%
- Classification of hematologic effects
- RBC parameters
- Control of erythropoiesis
- Instruments with animal-specific applications
- Hemoglobin concentration
- Red cell counting and sizing (RBC, MCV)
- Red cell counting and sizing (HCT, RDW)
- RBC vs. MCV: inverse relationship
- Calculated red cell indices & reticulocyte counting
- RBC and reticulocyte analysis
- Characteristics of young red cells
- Correlation of RBC data
- Increased red cell mass (HGB, HCT, RBC)
- Decreased red cell mass (HGB, HCT, RBC)
- Absolute decreased red cell mass
- Red cell loss (hemorrhage)
- Red cell destruction (hemolysis)
- Red cell loss or destruction
- Differences in RBC lifespan affect responses (1)
- Extramedullary hematopoiesis
- Decreased red cell production: causes
- Decreased red cell production: characteristics
- Differences in RBC lifespan affect responses (2)
- Anemia of chronic disease (1)
- Anemia of chronic disease (2)
- WBC parameters
- Counting and classifying leukocytes
- Advia
- Total WBC counts
- Species differences: lymphocyte/neutrophil ratio
- Leukocyte kinetics in health
- Increased leukocytes
- Decreased leukocytes
- Platelet parameters
- Platelets - overview
- Platelet counting and sizing
- Increased platelets
- Changes in platelet size
- Decreased platelets
- Hematopoiesis
- Bone marrow evaluation
- Summary
- Acknowledgements
- Abbreviations
Topics Covered
- Minimizing effects of preanalytical variables on hematology tests
- Proper use of reference intervals
- Evaluating rbc parameters
- Evaluating leukocyte parameters
- Evaluating platelet parameters
- Preparation and evaluation of bone marrow smears
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Talk Citation
Everds, N. (2009, August 26). Hematology interpretation for toxicity studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 29, 2023, from https://hstalks.com/bs/1349/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Nancy Everds has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.