We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Core hematology parameters
- Minimizing variability
- Physiological / procedural variability
- Effect of strain
- Effect of excitement / fear
- Effect of restraint stress on leukocytes (rats)
- Effect of collection time on leukocyte counts
- Effect of collection site (mice)
- Artifact
- Other contributors to variability
- Appropriate use of reference intervals
- Some good study design practices
- Purpose of hematology tests
- Predictability for human hematotoxicity >/= 90%
- Classification of hematologic effects
- RBC parameters
- Control of erythropoiesis
- Instruments with animal-specific applications
- Hemoglobin concentration
- Red cell counting and sizing (RBC, MCV)
- Red cell counting and sizing (HCT, RDW)
- RBC vs. MCV: inverse relationship
- Calculated red cell indices & reticulocyte counting
- RBC and reticulocyte analysis
- Characteristics of young red cells
- Correlation of RBC data
- Increased red cell mass (HGB, HCT, RBC)
- Decreased red cell mass (HGB, HCT, RBC)
- Absolute decreased red cell mass
- Red cell loss (hemorrhage)
- Red cell destruction (hemolysis)
- Red cell loss or destruction
- Differences in RBC lifespan affect responses (1)
- Extramedullary hematopoiesis
- Decreased red cell production: causes
- Decreased red cell production: characteristics
- Differences in RBC lifespan affect responses (2)
- Anemia of chronic disease (1)
- Anemia of chronic disease (2)
- WBC parameters
- Counting and classifying leukocytes
- Advia
- Total WBC counts
- Species differences: lymphocyte/neutrophil ratio
- Leukocyte kinetics in health
- Increased leukocytes
- Decreased leukocytes
- Platelet parameters
- Platelets - overview
- Platelet counting and sizing
- Increased platelets
- Changes in platelet size
- Decreased platelets
- Hematopoiesis
- Bone marrow evaluation
- Summary
- Acknowledgements
- Abbreviations
Topics Covered
- Minimizing effects of preanalytical variables on hematology tests
- Proper use of reference intervals
- Evaluating rbc parameters
- Evaluating leukocyte parameters
- Evaluating platelet parameters
- Preparation and evaluation of bone marrow smears
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Everds, N. (2009, August 26). Hematology interpretation for toxicity studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 29, 2023, from https://hstalks.com/bs/1349/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Nancy Everds has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
