Hematology interpretation for toxicity studies

Published on August 26, 2009   43 min

A selection of talks on Haematology

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0:00
Hello. My name is Nancy Everds and I'm a veterinary clinical pathologist at Amgen in Seattle Washington. Today I'm going to talk about the interpretation of hematologic parameters for toxicity studies.
0:14
Before we get very far into this talk, I want to go over what the core hematology parameters are. These are generally included in what we call the complete blood count. That includes red blood cell mass parameters which are red blood cell count hemoglobin and hematocrit. The red blood cell indices which are mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and red cell distribution width. The absolute reticulocyte count which is done on almost every toxicity study. The white blood cell count and absolute differential white blood cell counts and two platelet parameters usually the platelet count and the mean platelet volume. It's also important to go ahead and prepare a blood smear even though you may not need it to generate the above parameters because if you don't make it at the time of analysis, you can't go back and make that smear. It's really important to always prepare a blood smear.
1:09
One of the most important aspects of conducting hematology tests on toxicity studies is the minimization of variability. It's really critical to being able to generate interpretable results. Some of the potential sources of variability include physiologic effects, procedural effects, analytical effects, artifacts either during collection or analysis and just basic study design procedures that impact the clinical pathology result.

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Hematology interpretation for toxicity studies

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