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Printable Handouts
Navigable Slide Index
- Introduction
- Agenda
- Genetic toxicology: background
- Bacterial reverse mutation assay (Ames assay) (1)
- In vitro mammalian chromosome aberration assay
- CHO cell cytogenetic assay - aberrations
- CHO cell cytogenetic assay - polyploidy
- The MN assay as a surrogate for cytogenetics
- In vitro mammalian gene mutation test
- In vivo genotoxicity assays
- Current practices and future directions
- Genotoxicity assays - the standard battery (ICH)
- Bacterial reverse mutation assay (Ames assay) (2)
- Ames assay, sample results
- In vitro chromosome aberration assay
- In vitro mammalian cell gene mutation assays
- In silico (computational) SAR
- Genotoxicity testing during development
- Integration of genetox study results
- Issue management - positive responses
- Interpreting genetox toxicity results
- Genetic toxicity - case study
- Mechanistic use of the aberration assay
- Influence on carcinogenicity testing
- EMEA guidance for genotoxic impurities
- Staged TTC approach
- Summary
- References
- Thank you
Topics Covered
- Mutagenicity testing
- Clastogenicity testing
- Additional assays
- Regulatory genetic toxicology
- Current regulations
- In vitro mutagenicity and clastogenicity
- In silico
- Integration of results and data interpretation
- Genotoxic impurity testing
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Talk Citation
Bunch, R.T. (2009, July 30). Genetic toxicology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/GQUP9183.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Roderick Todd Bunch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.