• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome biorientation in yeast

  • Prof. Mike Stark
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Basic replication fork anatomy
3. Obstacles to replication fork progression
4. Topological stress ahead of replication fork
5. Topoisomerases remove topological stress
6. Topoisomerase II relaxes newly replicated strands
7. Topoisomerase II mechanism of work
8. Cellular response to template lesions in replication
9. Checkpoint responses to stalled forks
10. Fork stabilisation
11. Coping with DNA lesions in replication template
12. DNA repair by excision mechanisms
13. DNA damage bypass at the fork
14. Regulation of DNA damage bypass choice
15. DNA damage bypass: translesion synthesis
16. Translesion synthesis polymerases
17. DNA damage bypass: template switching models
18. Fork regression mechanisms
19. Template switching mechanisms
20. Recombination structures in template switching
21. Co-directional replication and transcription
22. Head-on collision of replication and transcription
23. Replication and transcription of ribosomal genes
24. Replication fork on rDNA
25. Protein roadblocks and Rrm3 helicase
26. Recombination and replication
27. Summary and conclusions

Topics Covered

• Replication fork anatomy
• Obstacles to replication fork progression
• Topological stress
• Fork stabilisation
• DNA repair
• DNA damage bypass
• Translesion synthesis
• Template switching models
• Fork regression mechanisms
• Co-directional replication and transcription

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on June 29, 2009

Financial Disclosures

• Dr. Luis Aragón has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.