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1. Introduction
2. Medical complications of obesity
3. Obesity is the primary risk factor for diabetes
4. Age-adjusted prevalence of hypertension vs. BMI
5. Metabolic syndrome: clinical identification
6. Twin epidemics: parallels in prevalence
7. Obesity and coronary heart disease mortality
8. Intentional weight loss and its health benefits
9. Data supporting life-style intervention
10. Weight loss and cardiovascular risk
11. US diabetes prevention program
12. Study interventions
13. Characteristics by treatment group assignment
14. DPP: lifestyle intervention
15. Dietary factors that affect energy intake
16. Weight-Reducing diet - recommended nutrients
17. DPP: effect of interventions on weight
18. DPP: mean change in leisure physical activity
19. DPP: cumulative incidence of diabetes
20. Mean change in blood pressure
21. Mean change in lipids (1)
22. Mean change in lipids (2)
23. Thrombogenic and inflammatory risk
24. Mean change in TPA
25. Mean change in fibrinogen
26. Mean change in CRP
27. CRP levels in obese postmenopausal women
28. Finnish diabetes prevention study
29. FDPS: goals of intervention
30. FDPS: effect of interventions on weight
31. FDPS: prevention of diabetes
32. FDPS: changes in clinical and metabolic variables
33. Hazard rate for diabetes and the change in weight
34. DPP and FDPS conclusions
35. LookAHEAD trial (1)
36. Look AHEAD trial (2)
37. Baseline characteristics of participants
38. LookAHEAD interventions
39. LookAHEAD: weight loss at 1-year
40. LookAHEAD: fitness change at 1-year
41. LookAHEAD: glycemia outcomes
42. LookAHEAD: blood pressure outcomes
43. LookAHEAD: lipid outcomes
44. LookAHEAD: other outcomes
45. LookAHEAD: conclusions
46. Trials of hypertension prevention, phase II
47. TOHP II: effect of intervention on weight
48. TOHP II: mean change in blood pressure
49. Effects of population-based BP reduction
50. Effect of modest weight loss on cholesterol
51. Effect of weight loss on HDL-C in type 2 diabetes
52. Weight loss: mechanisms for improvement in risks
53. Adipose tissue as endocrine cells
54. Obesity as a therapeutic target for prevention
55. Cancer incidence attributable to obesity
56. All cause mortality
57. Thank you

Topics Covered

• Medical complications of obesity
• Obesity is the primary risk factor for diabetes
• Age-adjusted prevalence of hypertension vs. BMI
• Metabolic syndrome: clinical identification
• Obesity and coronary heart disease mortality
• Data supporting life-style intervention
• Weight loss and cardiovascular risk
• US diabetes prevention program
• Study interventions
• DPP: lifestyle intervention
• Dietary factors that affect energy intake
• Weight-Reducing diet
• recommended nutrients
• Mean change in blood pressure
• Mean change in lipids
• Thrombogenic and inflammatory risk
• Mean change in TPA
• Mean change in fibrinogen
• Mean change in CRP
• Finnish diabetes prevention study
• Hazard rate for diabetes and the change in weight
• LookAHEAD trial
• Trials of hypertension prevention, phase II
• Effects of population-based BP reduction
• Effect of modest weight loss on cholesterol
• Adipose tissue as endocrine cells
• Obesity as a therapeutic target for prevention
• Cancer incidence attributable to obesity

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Xavier Pi-Sunyer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.