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1. Introduction
2. The cell cycle
3. Cohesin in the cell cycle
4. Chromatids arrangement at spindal pole
5. Tension-dependent reorientation
6. Kinetochore geometry (1)
7. Kinetochore geometry (2)
8. Chromatids separation in meiosis and mitosis
9. Kinetochore geometry during meiosis (1)
10. Kinetochore geometry during meiosis (2)
11. Organization of centromeres (1)
12. Monopolin complex in budding yeast
13. Models for mono-polar attachment at meiosis I
14. Organization of centromeres (2)
15. Cohesion complex in meiosis and mitosis (1)
16. Studies of chromosomes segregation at meiosis
17. Cohesin is defining kinetochore orientation
18. Rec8 vs. Rad21 at the centromere
19. Cohesion-mediated kinetochore orientation model
20. The central core cohesion in moa1 mutant
21. A lacO array in the core centromere
22. Excision of core centromeres (1)
23. Excision of core centromeres (2)
24. Cohesion depends on Moa1 as well as Rec8
25. Cohesion is disrupted at prophase II
26. Cohesion complex in meiosis and mitosis (2)
27. Centromeric resolution in mitosis
28. Disestablishment of cohesion during mitosis (1)
29. Disestablishment of cohesion during mitosis (2)
30. Kinetochore geometry of mono-orientation
31. Artificial tether at the core centromere
32. Artificial tether restores mono-orientation
33. Artificial tether induces mono-orientation in mitosis
34. Core centromeres regulate orientation
35. Tether applied to the non-cohered chromatids
36. Shugoshin allows segregation at meiosis II
37. Tether applied to the non-cohered chromosomes
38. Opposite tethers effects at centromeric regions
39. Kinetochore orientation is regulated by cohesion
40. Acknowledgements

Topics Covered

• The cell cycle
• Aurora B-dependent destabilization
• The attachment is stabilized under tension
• Tension-dependent reorientation
• Kinetochore geometry
• Organization of centromeres
• Budding yeast
• Two models to account for the mono-polar attachment at meiosis I
• Rec8 vs. Rad21 at the centromere
• Cohesion-mediated kinetochore orientation model
• Is the central core cohesion defective in moa1Δ?
• A lacO array in the core centromere
• Excision of core centromeres
• Cohesion at core centromeres depends on Moa1 as well as Rec8
• Cohesion at core centromeres is disrupted at prophase II
• Centromeric resolution in mitosis
• Core centromere is intrinsically prevented from establishment of cohesion
• Artificial tether at the core centromere
• Opposite effects of tethers at the core and peri-centromeric regions

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Watanabe, Y. (2009, April 30). Geometric regulation of kinetochore orientation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 4, 2025, from https://doi.org/10.69645/UCTU5710.
Export Citation (RIS)

Publication History

• Published on April 30, 2009
• Archived on January 15, 2020

Financial Disclosures

• Prof. Yoshinori Watanabe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.