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1. Introduction
2. The Metazoan life cycle
3. Meiosis versus Mitosis
4. Mitotic chromosome segregation
5. Differences between mitosis and meiosis
6. Overview of talk
7. Homologous recombination
8. Meiotic prophase I
9. DSB repair model (Szostak et al., 1983)
10. Detection of meiotic recombination intermediates
11. Detection of SEIs and dHJs
12. Non-crossovers are probably formed by SDSA
13. sHJs give rise to crossovers in S. pombe
14. Chiasmata link the homologues by cohesin
15. Programmed DSBs during meiosis
16. DSB formation does not only depend on Spo11
17. DSB formation restricted to leptotene, prophase I
18. DSB can be uncoupled from DNA replication
19. Mer2 is phosphorylated at multiple sites
20. Mer2 phosphorylation is essential
21. Mer2 phosphorylation and DNA replication
22. Processing the DSB (1)
23. Structure of the MRX/N complex
24. Processing the DSB (2)
25. Pairing of homologous DNAs and strand invasion
26. How do Rad51 and Dmc1 function together?
27. Other factors needed for homologous pairing
28. Assembly of the Rad51/Dmc1 filament
29. Simple model for the aid of accessory proteins
30. Resolving HJ and crossover formation
31. The ZMM proteins and Class I crossovers
32. Mer3 and Msh4-Msh5
33. The synaptonemal complex
34. The nucleation of Zip1 polymerization
35. Class I crossovers need specific resolution of dHJ
36. Class II crossovers depend on Mus81-Eme1/Mms4
37. Conclusion
38. Reference

Topics Covered

• The metazoan life cycle
• Meiosis vs. mitosis
• Mitotic chromosome segregation
• Models of homologous recombination and how it generates chiasmata
• Initiation of homologous recombination by programmed DNA double-strand breaks
• Mechanisms of double-strand break repair
• Mechanisms of crossover formation

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Gynaecology & Obstetrics

Talk Citation

Whitby, M. (2009, April 30). Recombination and the formation of chiasmata in meiosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/MVSG7893.
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Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Matthew Whitby has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.