• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome biorientation in yeast

  • Prof. Mike Stark
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The cell cycle consists of four distinct phases
3. The four phases of cell cycle
4. Cell cycle regulation
5. Two processes must alternate in cell division
6. Cell cycle machinery
7. Cell cycle checkpoints
8. The cell cycle engine
9. The role of cyclins and CDKs in cell cycle
10. Regulation of cyclin D-CKD activity
11. The regulation of cell cycle progression
12. Other roles of CDKs and cyclins (1)
13. Other roles of CDKs and cyclins (2)
14. Cell cycle and pRb family proteins
15. Interaction of pRb and E2F transcription factors
16. What is the nature of this interaction?
17. Cell cycle control pathways
18. The pRb and p53 pathways
19. Conclusions
20. Thank you

Topics Covered

• The cell cycle is a complex system which is highly regulated in a temporal manner, via checkpoints and positive and negative feedback loops
• Two processes must alternate during eukaryotic cell division: S-phase and M-phase entry
• Cell cycle checkpoints
• The cell cycle engine
• Cyclin D-CDK activity
• Not all CDKs and cyclins are involved in the regulation of cell cycle
• Cell cycle and pRb family proteins
• Cell cycle control pathways

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Antonio Giordano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.