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- Chromosome Duplication
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1. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Spindle Assembly and Chromosome Segregation
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2. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- The Cell Cycle in Development and Cancer
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3. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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4. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Archived Lectures *These may not cover the latest advances in the field
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5. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
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6. The spindle checkpoint
- Dr. Kevin Hardwick
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7. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
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8. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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9. The G2/M transition
- Prof. Dr. René Medema
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11. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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12. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
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13. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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14. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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15. START control in yeast
- Prof. Curt Wittenberg
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16. The pRB/E2F pathway
- Prof. Jacqueline Lees
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17. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
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18. Replication licensing
- Prof. Julian Blow
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19. Initiation of DNA replication
- Prof. Bruce Stillman
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20. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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21. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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22. Mitotic chromosome condensation
- Prof. Andrew Belmont
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23. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
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25. The DNA damage response
- Dr. Vincenzo Costanzo
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26. Bipolar spindle assembly
- Dr. Eric Karsenti
Printable Handouts
Navigable Slide Index
- Introduction
- The cell cycle consists of four distinct phases
- The four phases of cell cycle
- Cell cycle regulation
- Two processes must alternate in cell division
- Cell cycle machinery
- Cell cycle checkpoints
- The cell cycle engine
- The role of cyclins and CDKs in cell cycle
- Regulation of cyclin D-CKD activity
- The regulation of cell cycle progression
- Other roles of CDKs and cyclins (1)
- Other roles of CDKs and cyclins (2)
- Cell cycle and pRb family proteins
- Interaction of pRb and E2F transcription factors
- What is the nature of this interaction?
- Cell cycle control pathways
- The pRb and p53 pathways
- Conclusions
- Thank you
Topics Covered
- The cell cycle is a complex system which is highly regulated in a temporal manner, via checkpoints and positive and negative feedback loops
- Two processes must alternate during eukaryotic cell division: S-phase and M-phase entry
- Cell cycle checkpoints
- The cell cycle engine
- Cyclin D-CDK activity
- Not all CDKs and cyclins are involved in the regulation of cell cycle
- Cell cycle and pRb family proteins
- Cell cycle control pathways
Talk Citation
Giordano, A. (2009, April 30). Cell cycle: a complex network of signals regulating cell proliferation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 4, 2025, from https://doi.org/10.69645/OYVA8686.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Antonio Giordano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Cell cycle: a complex network of signals regulating cell proliferation
A selection of talks on Cell Biology
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