• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome biorientation in yeast

  • Prof. Mike Stark
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Cell division
3. DNA replication / Chromosome segregation
4. Alternating waves of activity
5. Lessons from cell fusion (1)
6. Lessons from cell fusion (2)
7. Lessons from cell fusion (3)
8. Interdependence
9. Cyclins (1)
10. Cyclins (2)
11. Cyclin/cdks
12. Cyclin/cdks in mammals
13. Cyclin B/cdk1
14. Cdk activation
15. Bistability (1)
16. Bistability (2)
17. Polo-like kinase-1 (1)
18. Polo-like kinase-1 (2)
19. Function of Plk1 in mitosis
20. Checkpoints (1)
21. Checkpoints (2)
22. G2 checkpoint
23. Checkpoint recovery (1)
24. Checkpoint recovery (2)
25. Plk1 in checkpoint recovery (1)
26. Plk1 in checkpoint recovery (2)
27. Plk1 controls recovery
28. Claspin (1)
29. Claspin (2)
30. Plk1 controls checkpoint silencing
31. Plk1 activation (1)
32. Plk1 activation (2)
33. Plk1 activity gradually increases from G2 to M
34. T210-phosphorylation in recovery
35. Plk1 activity requires T210-phosphorylation
36. T210 phosphorylation
37. Bora specifically activates Aurora A
38. Aurora A is responsible for activation of Plk1 in G2
39. Aurora A controls Plk1 activation
40. Bora controls recovery
41. Mitotic entry
42. Plk1 controls checkpoint recovery
43. Acknowledgements

Topics Covered

• Cell Division
• Cell fusion experiments
• The cyclins and Cdks
• Mitosis
• Cyclin B1/Cdk1
• Feedback loops in Cdk activation
• Polo-like kinase-1
• Checkpoints
• Checkpoint recovery

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Dr. René Medema has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.