Gene structure, expression and regulation: DNA structure and replication
37 min
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- Chromosome Duplication
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35 min
1. Nucleosome assembly during DNA replication- Dr. Alain Verreault
- Spindle Assembly and Chromosome Segregation
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54 min
2. Chromosome bi-orientation in yeast- Prof. Mike Stark
- Prof. Tomo Tanaka
- The Cell Cycle in Development and Cancer
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62 min
3. Mouse models to investigate cell cycle and cancer- Dr. Philipp Kaldis
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47 min
4. The Myc transcription factor network- Prof. Robert N. Eisenman
- Archived Lectures *These may not cover the latest advances in the field
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24 min
5. Geometric regulation of kinetochore orientation- Prof. Yoshinori Watanabe
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54 min
6. The spindle checkpoint- Dr. Kevin Hardwick
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39 min
7. Cleavage furrow formation and ingression during animal cytokinesis- Dr. Pier Paolo D'Avino
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27 min
8. Spindle movement and checkpoint control during mitosis in yeast- Prof. John Cooper
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43 min
9. The G2/M transition- Prof. Dr. René Medema
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43 min
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30 min
11. Role and regulation of Cdk inhibitors in development and cancer- Prof. Martine Roussel
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58 min
12. Recombination and the formation of chiasmata in meiosis- Prof. Matthew Whitby
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18 min
13. Cell cycle: a complex network of signals regulating cell proliferation- Prof. Antonio Giordano
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40 min
14. Drug discovery and target validation in the p53 pathway- Prof. Sir David Lane
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37 min
15. START control in yeast- Prof. Curt Wittenberg
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33 min
16. The pRB/E2F pathway- Prof. Jacqueline Lees
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35 min
17. Cell cycle control by the ubiquitin system in mammals- Prof. Michele Pagano
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47 min
18. Replication licensing- Prof. Julian Blow
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51 min
19. Initiation of DNA replication- Prof. Bruce Stillman
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48 min
20. Regulation of replication fork progression and stability- Dr. Luis Aragón
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27 min
21. Sister chromatid cohesion: simple concept, complex reality- Prof. Douglas Koshland
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50 min
22. Mitotic chromosome condensation- Prof. Andrew Belmont
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33 min
23. Centrosome duplication and separation in animal cells- Prof. Andrew Fry
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48 min
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34 min
25. The DNA damage response- Dr. Vincenzo Costanzo
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30 min
26. Bipolar spindle assembly- Dr. Eric Karsenti
Printable Handouts
Navigable Slide Index
- Introduction
- Cell division
- DNA replication / Chromosome segregation
- Alternating waves of activity
- Lessons from cell fusion (1)
- Lessons from cell fusion (2)
- Lessons from cell fusion (3)
- Interdependence
- Cyclins (1)
- Cyclins (2)
- Cyclin/cdks
- Cyclin/cdks in mammals
- Cyclin B/cdk1
- Cdk activation
- Bistability (1)
- Bistability (2)
- Polo-like kinase-1 (1)
- Polo-like kinase-1 (2)
- Function of Plk1 in mitosis
- Checkpoints (1)
- Checkpoints (2)
- G2 checkpoint
- Checkpoint recovery (1)
- Checkpoint recovery (2)
- Plk1 in checkpoint recovery (1)
- Plk1 in checkpoint recovery (2)
- Plk1 controls recovery
- Claspin (1)
- Claspin (2)
- Plk1 controls checkpoint silencing
- Plk1 activation (1)
- Plk1 activation (2)
- Plk1 activity gradually increases from G2 to M
- T210-phosphorylation in recovery
- Plk1 activity requires T210-phosphorylation
- T210 phosphorylation
- Bora specifically activates Aurora A
- Aurora A is responsible for activation of Plk1 in G2
- Aurora A controls Plk1 activation
- Bora controls recovery
- Mitotic entry
- Plk1 controls checkpoint recovery
- Acknowledgements
Topics Covered
- Cell Division
- Cell fusion experiments
- The cyclins and Cdks
- Mitosis
- Cyclin B1/Cdk1
- Feedback loops in Cdk activation
- Polo-like kinase-1
- Checkpoints
- Checkpoint recovery
Talk Citation
Medema, R. (2009, April 30). The G2/M transition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 6, 2025, from https://doi.org/10.69645/WWXO1280.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dr. René Medema has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
