Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Cell division
3. DNA replication / Chromosome segregation
4. Alternating waves of activity
5. Lessons from cell fusion (1)
6. Lessons from cell fusion (2)
7. Lessons from cell fusion (3)
8. Interdependence
9. Cyclins (1)
10. Cyclins (2)
11. Cyclin/cdks
12. Cyclin/cdks in mammals
13. Cyclin B/cdk1
14. Cdk activation
15. Bistability (1)
16. Bistability (2)
17. Polo-like kinase-1 (1)
18. Polo-like kinase-1 (2)
19. Function of Plk1 in mitosis
20. Checkpoints (1)
21. Checkpoints (2)
22. G2 checkpoint
23. Checkpoint recovery (1)
24. Checkpoint recovery (2)
25. Plk1 in checkpoint recovery (1)
26. Plk1 in checkpoint recovery (2)
27. Plk1 controls recovery
28. Claspin (1)
29. Claspin (2)
30. Plk1 controls checkpoint silencing
31. Plk1 activation (1)
32. Plk1 activation (2)
33. Plk1 activity gradually increases from G2 to M
34. T210-phosphorylation in recovery
35. Plk1 activity requires T210-phosphorylation
36. T210 phosphorylation
37. Bora specifically activates Aurora A
38. Aurora A is responsible for activation of Plk1 in G2
39. Aurora A controls Plk1 activation
40. Bora controls recovery
41. Mitotic entry
42. Plk1 controls checkpoint recovery
43. Acknowledgements

Topics Covered

• Cell Division
• Cell fusion experiments
• The cyclins and Cdks
• Mitosis
• Cyclin B1/Cdk1
• Feedback loops in Cdk activation
• Polo-like kinase-1
• Checkpoints
• Checkpoint recovery

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Dr. René Medema has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.