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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- Genomic instability in cancer
- DNA structure checkpoint
- ATM, ATR and related proteins
- Ataxia Telangiectasia- clinical features
- ATM dependant DNA damage response in cancer
- Oncogenes activate DNA damage response
- Oncogenes induce aberrant DNA replication
- ATM, ATR targets
- Xenopus laevis egg extract as model system
- Activation of DNA damage response in the model
- In vitro reconstitution of an ATM checkpoint
- Activation of the DNA damage checkpoint & Cdc45
- DSB block Cdc45 loading
- Sensing the DNA break
- Mre11-Rad50-Nbs1 complex
- Sensing DNA double strand breaks: current model
- ATM activation by ssDNA molecules
- ssDNA oligo generation is MRN dependant
- ssDNA oligos lead to diffuse ATM activation
- A second messenger of DNA damage response
- ATM, ATR and Mre11 complex deficiencies
- ATM and ATR in unchallenged S-phase
- ATM and ATR might prevent DSB accumulation
- ATM and ATR required to restart replication forks
- ATM and ATR promote reloading of Pol Epsilon
- ATM and ATR promote recapture of DSB
- Mre11 complex required to restart replication forks
- ATM and ATR function - summary
- DNA structure checkpoint and mitotic catastrophe
- ATM, ATR targets in mitosis after DNA damage
- XCep63 mutant makes spindles resistant to ATM
- Centrosome as target of DNA damage response
- Acknowledgements
Topics Covered
- Genomic instability in cancer
- DNA structure checkpoint
- ATM, ATR and related proteins
- Xenopus laevis egg extract as a model system
- Sensing the DNA break
- Mre11/Rad50/Nbs1 complex
- Sensing DNA double strand breaks: current model
- ATM activation by ssDNA molecules
- ssDNA oligo generation is MRN dependent
- ATM, ATR and Mre11 complex deficiency in vertebrates
- DNA structure checkpoint and mitotic catastrophe in vertebrates
- ATM/ATR targets in mitosis after DNA damage
- Centrosome as a target of DNA damage response
Talk Citation
Costanzo, V. (2009, April 30). The DNA damage response [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2024, from https://hstalks.com/bs/1265/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Vincenzo Costanzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.