• Chromosome Duplication
• 35 min
  1. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Spindle Assembly and Chromosome Segregation
• 54 min
  2. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• The Cell Cycle in Development and Cancer
• 62 min
  3. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 47 min
  4. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  5. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe
• 54 min
  6. The spindle checkpoint

  • Dr. Kevin Hardwick
• 39 min
  7. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• 27 min
  8. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  9. The G2/M transition

  • Prof. Dr. René Medema
• 43 min
  10. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• 30 min
  11. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 58 min
  12. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• 18 min
  13. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  14. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 37 min
  15. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  16. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  17. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• 47 min
  18. Replication licensing

  • Prof. Julian Blow
• 51 min
  19. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  20. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 27 min
  21. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  22. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  23. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• 48 min
  24. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 34 min
  25. The DNA damage response

  • Dr. Vincenzo Costanzo
• 30 min
  26. Bipolar spindle assembly

  • Dr. Eric Karsenti

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genomic instability in cancer
3. DNA structure checkpoint
4. ATM, ATR and related proteins
5. Ataxia Telangiectasia- clinical features
6. ATM dependant DNA damage response in cancer
7. Oncogenes activate DNA damage response
8. Oncogenes induce aberrant DNA replication
9. ATM, ATR targets
10. Xenopus laevis egg extract as model system
11. Activation of DNA damage response in the model
12. In vitro reconstitution of an ATM checkpoint
13. Activation of the DNA damage checkpoint & Cdc45
14. DSB block Cdc45 loading
15. Sensing the DNA break
16. Mre11-Rad50-Nbs1 complex
17. Sensing DNA double strand breaks: current model
18. ATM activation by ssDNA molecules
19. ssDNA oligo generation is MRN dependant
20. ssDNA oligos lead to diffuse ATM activation
21. A second messenger of DNA damage response
22. ATM, ATR and Mre11 complex deficiencies
23. ATM and ATR in unchallenged S-phase
24. ATM and ATR might prevent DSB accumulation
25. ATM and ATR required to restart replication forks
26. ATM and ATR promote reloading of Pol Epsilon
27. ATM and ATR promote recapture of DSB
28. Mre11 complex required to restart replication forks
29. ATM and ATR function - summary
30. DNA structure checkpoint and mitotic catastrophe
31. ATM, ATR targets in mitosis after DNA damage
32. XCep63 mutant makes spindles resistant to ATM
33. Centrosome as target of DNA damage response
34. Acknowledgements

Topics Covered

• Genomic instability in cancer
• DNA structure checkpoint
• ATM, ATR and related proteins
• Xenopus laevis egg extract as a model system
• Sensing the DNA break
• Mre11/Rad50/Nbs1 complex
• Sensing DNA double strand breaks: current model
• ATM activation by ssDNA molecules
• ssDNA oligo generation is MRN dependent
• ATM, ATR and Mre11 complex deficiency in vertebrates
• DNA structure checkpoint and mitotic catastrophe in vertebrates
• ATM/ATR targets in mitosis after DNA damage
• Centrosome as a target of DNA damage response

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Dr. Vincenzo Costanzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.