Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genomic instability in cancer
3. DNA structure checkpoint
4. ATM, ATR and related proteins
5. Ataxia Telangiectasia- clinical features
6. ATM dependant DNA damage response in cancer
7. Oncogenes activate DNA damage response
8. Oncogenes induce aberrant DNA replication
9. ATM, ATR targets
10. Xenopus laevis egg extract as model system
11. Activation of DNA damage response in the model
12. In vitro reconstitution of an ATM checkpoint
13. Activation of the DNA damage checkpoint & Cdc45
14. DSB block Cdc45 loading
15. Sensing the DNA break
16. Mre11-Rad50-Nbs1 complex
17. Sensing DNA double strand breaks: current model
18. ATM activation by ssDNA molecules
19. ssDNA oligo generation is MRN dependant
20. ssDNA oligos lead to diffuse ATM activation
21. A second messenger of DNA damage response
22. ATM, ATR and Mre11 complex deficiencies
23. ATM and ATR in unchallenged S-phase
24. ATM and ATR might prevent DSB accumulation
25. ATM and ATR required to restart replication forks
26. ATM and ATR promote reloading of Pol Epsilon
27. ATM and ATR promote recapture of DSB
28. Mre11 complex required to restart replication forks
29. ATM and ATR function - summary
30. DNA structure checkpoint and mitotic catastrophe
31. ATM, ATR targets in mitosis after DNA damage
32. XCep63 mutant makes spindles resistant to ATM
33. Centrosome as target of DNA damage response
34. Acknowledgements

Topics Covered

• Genomic instability in cancer
• DNA structure checkpoint
• ATM, ATR and related proteins
• Xenopus laevis egg extract as a model system
• Sensing the DNA break
• Mre11/Rad50/Nbs1 complex
• Sensing DNA double strand breaks: current model
• ATM activation by ssDNA molecules
• ssDNA oligo generation is MRN dependent
• ATM, ATR and Mre11 complex deficiency in vertebrates
• DNA structure checkpoint and mitotic catastrophe in vertebrates
• ATM/ATR targets in mitosis after DNA damage
• Centrosome as a target of DNA damage response

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Dr. Vincenzo Costanzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.