• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Cytokinesis is the final act of cell division
3. Different populations of microtubules in cytokinesis
4. Co-ordination of events during cytokinesis
5. RhoA effect on actomyosin ring
6. Inactivation of RhoA causes cytokinesis failure
7. RhoA activation is a key event for actomyosin ring
8. What determines the cleavage plane position?
9. Astral relaxation
10. Disassembly of aster microtubules
11. Astral microtubules inhibit RhoA activation
12. Equatorial and central spindle stimulation
13. Microtubules are necessary for RhoA activation
14. Microtubules contact the future cleavage site (1)
15. Microtubules contact the future cleavage site (2)
16. Dual role for microtubules in RhoA activation
17. Molecular nature of furrow inducing signal
18. RacGAP component of centralspindlin
19. Both pav and RacGAP are necessary for furrowing
20. Localization of centralspindlin prior to furrowing
21. Regulation of the centralspindlin accumulation
22. Cdk1 inhibits MKLP-1-microtubules interaction
23. RacGAP promotes RhoA activation
24. Cleavage furrow formation and ingression (1)
25. Properties of the RacGAP component
26. Cleavage furrow formation and ingression (2)
27. CD8:RacGAP promotes ectopic furrowing
28. CD8::RacGAP50C induces ectopic furrows
29. Ectopic furrows induced by CD8::RacGAP
30. How can CD8:RacGAP recruit anillin?
31. Anillin, a scaffold protein
32. Anillin localization during the cell cycle
33. Anillin equatorial recruitment
34. Proteins interacting with anillin
35. RacGAP50C co-localizes with anillin
36. Anillin binds RacGAP50C through its C terminus
37. RacGAP50C binds anillin and pav in different sites
38. Anillin-summary
39. Membrane formation during cytokinesis
40. Sources of new membrane at the cleavage site
41. Internal membrane reservoirs
42. Molecules involved in membrane trafficking
43. Membrane trafficking during cytokinesis
44. RacGAP interacts with FIP3
45. RacGAP is a key regulator in cytokinesis
46. Acknowledgments
47. Appendix: references

Topics Covered

• Co-ordination of multiple events during cytokinesis
• Assembly and contraction of the actomyosin ring: the role of RhoA
• Cleavage plane determination
• The role of microtubules in positioning the cleavage plane
• The molecular nature of the furrow inducing signal
• The centralspindlin complex
• The role of Anillin during cytokinesis
• Interaction between Anillin and centralspindlin connects the contractile ring with spindle microtubules
• Membrane formation during cytokinesis
• The origin of new membrane for the cleavage site
• Molecules involved in membrane trafficking during cytokinesis
• The multiple roles of the RacGAP component of the centralspindlin complex during cytokinesis

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Dr. Pier Paolo D'Avino has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.