• Chromosome Duplication
• 35 min
  1. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Spindle Assembly and Chromosome Segregation
• 54 min
  2. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• The Cell Cycle in Development and Cancer
• 62 min
  3. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 47 min
  4. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  5. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe
• 54 min
  6. The spindle checkpoint

  • Dr. Kevin Hardwick
• 39 min
  7. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• 27 min
  8. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  9. The G2/M transition

  • Prof. Dr. René Medema
• 43 min
  10. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• 30 min
  11. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 58 min
  12. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• 18 min
  13. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  14. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 37 min
  15. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  16. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  17. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• 47 min
  18. Replication licensing

  • Prof. Julian Blow
• 51 min
  19. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  20. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 27 min
  21. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  22. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  23. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• 48 min
  24. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 34 min
  25. The DNA damage response

  • Dr. Vincenzo Costanzo
• 30 min
  26. Bipolar spindle assembly

  • Dr. Eric Karsenti

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The cell cycle
3. Cell division in living cells
4. The different stages of cell division
5. Cancer and chromosomal instability
6. Cell division errors and aneuploidy
7. Chromosomal passenger proteins
8. Chromosomal passenger complex (CPC)
9. Mitosis when CPC function is perturbed
10. Cytokinesis when CPC function is perturbed
11. The CPC is multifunctional
12. The CPC: regulation of Aurora B kinase activity
13. The CPC: regulation of Aurora B localization
14. Kinetochores: the microtubule binding sites
15. Requirements for faithful chromosome segregation
16. Monastrol - reversible inhibitor of Eg5
17. The CPC is needed for bi-oriented attachments
18. The CPC corrects improper attachments
19. CPC substrates
20. Regulation of Hec1/Ndc80 by Aurora B
21. CPC is required for a functional mitotic checkpoint
22. The mitotic checkpoint inhibits the APC/C
23. CPC and incorrectly attached chromosomes
24. Unattached kinetochores activate checkpoint
25. Systematic screen for INCENP mutants
26. The CPC controls mitotic checkpoint directly
27. Summary: centromere function of the CPC
28. Survivin dynamically exchanges with centromeres
29. From metaphase to anaphase
30. Cytokinesis failure when CPC function is perturbed
31. Requirements for cytokinesis
32. Regulation of cytokinesis by the CPC
33. Perturbed CPC function results in cell death
34. Aurora kinase inhibitors as anti-cancer drugs
35. CPC orchestrates cell division at different levels
36. Future directions
37. Acknowledgements
38. References

Topics Covered

• Cell division
• Cancer and chromosomal instability
• Cell division errors and aneuploidy
• The chromosomal passenger complex (CPC)
• The CPC executes various functions in the dividing cell
• Regulation of Aurora B kinase activity and localization
• Centromeres and kinetochores
• Perturbation of the CPC results in severe chromosome congression and segregation defects
• Requirements for faithful chromosome segregation
• The CPC promotes bi-orientation by influencing kinetochore-microtubule interactions
• CPC substrates at the kinetochore
• Hec1/Ndc80
• The CPC is essential for a functional mitotic checkpoint
• The dynamic localization at centromeres
• Transfer to the central spindle
• The CPC and cytokinesis
• Aurora kinase inhibitors as anti-cancer drugs

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Dr. Susanne Lens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.