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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- The cell cycle
- Cell division in living cells
- The different stages of cell division
- Cancer and chromosomal instability
- Cell division errors and aneuploidy
- Chromosomal passenger proteins
- Chromosomal passenger complex (CPC)
- Mitosis when CPC function is perturbed
- Cytokinesis when CPC function is perturbed
- The CPC is multifunctional
- The CPC: regulation of Aurora B kinase activity
- The CPC: regulation of Aurora B localization
- Kinetochores: the microtubule binding sites
- Requirements for faithful chromosome segregation
- Monastrol - reversible inhibitor of Eg5
- The CPC is needed for bi-oriented attachments
- The CPC corrects improper attachments
- CPC substrates
- Regulation of Hec1/Ndc80 by Aurora B
- CPC is required for a functional mitotic checkpoint
- The mitotic checkpoint inhibits the APC/C
- CPC and incorrectly attached chromosomes
- Unattached kinetochores activate checkpoint
- Systematic screen for INCENP mutants
- The CPC controls mitotic checkpoint directly
- Summary: centromere function of the CPC
- Survivin dynamically exchanges with centromeres
- From metaphase to anaphase
- Cytokinesis failure when CPC function is perturbed
- Requirements for cytokinesis
- Regulation of cytokinesis by the CPC
- Perturbed CPC function results in cell death
- Aurora kinase inhibitors as anti-cancer drugs
- CPC orchestrates cell division at different levels
- Future directions
- Acknowledgements
- References
Topics Covered
- Cell division
- Cancer and chromosomal instability
- Cell division errors and aneuploidy
- The chromosomal passenger complex (CPC)
- The CPC executes various functions in the dividing cell
- Regulation of Aurora B kinase activity and localization
- Centromeres and kinetochores
- Perturbation of the CPC results in severe chromosome congression and segregation defects
- Requirements for faithful chromosome segregation
- The CPC promotes bi-orientation by influencing kinetochore-microtubule interactions
- CPC substrates at the kinetochore
- Hec1/Ndc80
- The CPC is essential for a functional mitotic checkpoint
- The dynamic localization at centromeres
- Transfer to the central spindle
- The CPC and cytokinesis
- Aurora kinase inhibitors as anti-cancer drugs
Talk Citation
Lens, S. (2009, April 30). Regulation of mammalian cell division by the chromosomal passenger complex [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1263/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Susanne Lens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Regulation of mammalian cell division by the chromosomal passenger complex
Published on April 30, 2009
43 min
A selection of talks on Cell Biology
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