• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome biorientation in yeast

  • Prof. Mike Stark
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The cell cycle
3. Cell division in living cells
4. The different stages of cell division
5. Cancer and chromosomal instability
6. Cell division errors and aneuploidy
7. Chromosomal passenger proteins
8. Chromosomal passenger complex (CPC)
9. Mitosis when CPC function is perturbed
10. Cytokinesis when CPC function is perturbed
11. The CPC is multifunctional
12. The CPC: regulation of Aurora B kinase activity
13. The CPC: regulation of Aurora B localization
14. Kinetochores: the microtubule binding sites
15. Requirements for faithful chromosome segregation
16. Monastrol - reversible inhibitor of Eg5
17. The CPC is needed for bi-oriented attachments
18. The CPC corrects improper attachments
19. CPC substrates
20. Regulation of Hec1/Ndc80 by Aurora B
21. CPC is required for a functional mitotic checkpoint
22. The mitotic checkpoint inhibits the APC/C
23. CPC and incorrectly attached chromosomes
24. Unattached kinetochores activate checkpoint
25. Systematic screen for INCENP mutants
26. The CPC controls mitotic checkpoint directly
27. Summary: centromere function of the CPC
28. Survivin dynamically exchanges with centromeres
29. From metaphase to anaphase
30. Cytokinesis failure when CPC function is perturbed
31. Requirements for cytokinesis
32. Regulation of cytokinesis by the CPC
33. Perturbed CPC function results in cell death
34. Aurora kinase inhibitors as anti-cancer drugs
35. CPC orchestrates cell division at different levels
36. Future directions
37. Acknowledgements
38. References

Topics Covered

• Cell division
• Cancer and chromosomal instability
• Cell division errors and aneuploidy
• The chromosomal passenger complex (CPC)
• The CPC executes various functions in the dividing cell
• Regulation of Aurora B kinase activity and localization
• Centromeres and kinetochores
• Perturbation of the CPC results in severe chromosome congression and segregation defects
• Requirements for faithful chromosome segregation
• The CPC promotes bi-orientation by influencing kinetochore-microtubule interactions
• CPC substrates at the kinetochore
• Hec1/Ndc80
• The CPC is essential for a functional mitotic checkpoint
• The dynamic localization at centromeres
• Transfer to the central spindle
• The CPC and cytokinesis
• Aurora kinase inhibitors as anti-cancer drugs

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Dr. Susanne Lens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.