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Printable Handouts
Navigable Slide Index
- Introduction
- The cell cycle
- Cell division in living cells
- The different stages of cell division
- Cancer and chromosomal instability
- Cell division errors and aneuploidy
- Chromosomal passenger proteins
- Chromosomal passenger complex (CPC)
- Mitosis when CPC function is perturbed
- Cytokinesis when CPC function is perturbed
- The CPC is multifunctional
- The CPC: regulation of Aurora B kinase activity
- The CPC: regulation of Aurora B localization
- Kinetochores: the microtubule binding sites
- Requirements for faithful chromosome segregation
- Monastrol - reversible inhibitor of Eg5
- The CPC is needed for bi-oriented attachments
- The CPC corrects improper attachments
- CPC substrates
- Regulation of Hec1/Ndc80 by Aurora B
- CPC is required for a functional mitotic checkpoint
- The mitotic checkpoint inhibits the APC/C
- CPC and incorrectly attached chromosomes
- Unattached kinetochores activate checkpoint
- Systematic screen for INCENP mutants
- The CPC controls mitotic checkpoint directly
- Summary: centromere function of the CPC
- Survivin dynamically exchanges with centromeres
- From metaphase to anaphase
- Cytokinesis failure when CPC function is perturbed
- Requirements for cytokinesis
- Regulation of cytokinesis by the CPC
- Perturbed CPC function results in cell death
- Aurora kinase inhibitors as anti-cancer drugs
- CPC orchestrates cell division at different levels
- Future directions
- Acknowledgements
- References
Topics Covered
- Cell division
- Cancer and chromosomal instability
- Cell division errors and aneuploidy
- The chromosomal passenger complex (CPC)
- The CPC executes various functions in the dividing cell
- Regulation of Aurora B kinase activity and localization
- Centromeres and kinetochores
- Perturbation of the CPC results in severe chromosome congression and segregation defects
- Requirements for faithful chromosome segregation
- The CPC promotes bi-orientation by influencing kinetochore-microtubule interactions
- CPC substrates at the kinetochore
- Hec1/Ndc80
- The CPC is essential for a functional mitotic checkpoint
- The dynamic localization at centromeres
- Transfer to the central spindle
- The CPC and cytokinesis
- Aurora kinase inhibitors as anti-cancer drugs
Talk Citation
Lens, S. (2009, April 30). Regulation of mammalian cell division by the chromosomal passenger complex [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/MBQX8507.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Susanne Lens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Regulation of mammalian cell division by the chromosomal passenger complex
Published on April 30, 2009
43 min
A selection of talks on Cell Biology
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