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1. Introduction
2. The cell cycle
3. Cell division in living cells
4. The different stages of cell division
5. Cancer and chromosomal instability
6. Cell division errors and aneuploidy
7. Chromosomal passenger proteins
8. Chromosomal passenger complex (CPC)
9. Mitosis when CPC function is perturbed
10. Cytokinesis when CPC function is perturbed
11. The CPC is multifunctional
12. The CPC: regulation of Aurora B kinase activity
13. The CPC: regulation of Aurora B localization
14. Kinetochores: the microtubule binding sites
15. Requirements for faithful chromosome segregation
16. Monastrol - reversible inhibitor of Eg5
17. The CPC is needed for bi-oriented attachments
18. The CPC corrects improper attachments
19. CPC substrates
20. Regulation of Hec1/Ndc80 by Aurora B
21. CPC is required for a functional mitotic checkpoint
22. The mitotic checkpoint inhibits the APC/C
23. CPC and incorrectly attached chromosomes
24. Unattached kinetochores activate checkpoint
25. Systematic screen for INCENP mutants
26. The CPC controls mitotic checkpoint directly
27. Summary: centromere function of the CPC
28. Survivin dynamically exchanges with centromeres
29. From metaphase to anaphase
30. Cytokinesis failure when CPC function is perturbed
31. Requirements for cytokinesis
32. Regulation of cytokinesis by the CPC
33. Perturbed CPC function results in cell death
34. Aurora kinase inhibitors as anti-cancer drugs
35. CPC orchestrates cell division at different levels
36. Future directions
37. Acknowledgements
38. References

Topics Covered

• Cell division
• Cancer and chromosomal instability
• Cell division errors and aneuploidy
• The chromosomal passenger complex (CPC)
• The CPC executes various functions in the dividing cell
• Regulation of Aurora B kinase activity and localization
• Centromeres and kinetochores
• Perturbation of the CPC results in severe chromosome congression and segregation defects
• Requirements for faithful chromosome segregation
• The CPC promotes bi-orientation by influencing kinetochore-microtubule interactions
• CPC substrates at the kinetochore
• Hec1/Ndc80
• The CPC is essential for a functional mitotic checkpoint
• The dynamic localization at centromeres
• Transfer to the central spindle
• The CPC and cytokinesis
• Aurora kinase inhibitors as anti-cancer drugs

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Lens, S. (2009, April 30). Regulation of mammalian cell division by the chromosomal passenger complex [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 25, 2023, from https://hstalks.com/bs/1263/.
Export Citation (RIS)

Publication History

• Published on April 30, 2009

Financial Disclosures

• Dr. Susanne Lens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.