• Chromosome Duplication
• 35 min
  1. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Spindle Assembly and Chromosome Segregation
• 54 min
  2. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• The Cell Cycle in Development and Cancer
• 62 min
  3. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 47 min
  4. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  5. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe
• 54 min
  6. The spindle checkpoint

  • Dr. Kevin Hardwick
• 39 min
  7. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• 27 min
  8. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  9. The G2/M transition

  • Prof. Dr. René Medema
• 43 min
  10. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• 30 min
  11. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 58 min
  12. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• 18 min
  13. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  14. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 37 min
  15. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  16. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  17. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• 47 min
  18. Replication licensing

  • Prof. Julian Blow
• 51 min
  19. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  20. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 27 min
  21. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  22. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  23. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• 48 min
  24. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 34 min
  25. The DNA damage response

  • Dr. Vincenzo Costanzo
• 30 min
  26. Bipolar spindle assembly

  • Dr. Eric Karsenti

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The mitotic spindle of animal cells
3. Microtubule function throughout cell cycle
4. Microtubules are highly dynamic during mitosis
5. Dynamics of an animal cell spindle
6. A plant cell spindle
7. Spindle questions
8. Models of spindle assembly (1)
9. The notion of cytoplasmic state
10. Models of spindle assembly (2)
11. The frog egg extract system
12. Global regulation of microtubule dynamics
13. CDK1 and microtubule tip binding proteins network
14. Local microtubule nucleation around chromosomes
15. Local stabilization around chromosomes
16. Bipolarity and metaphase plate assembly
17. Signaling pathway for the microtubule system
18. Model of the Ran system
19. Calculating spatio-temporal evolution
20. Multiple gradients of signaling molecules
21. Short and long range effects of signaling gradients
22. TPX2 dependent local microtubule nucleation
23. CDK11 required for centrosomal spindle bipolarity
24. How microtubules organize into a bipolar array?
25. Motor-dependent bipolar spindle assembly
26. Spindle self-organization with centrosomes
27. Tubulin fluxes from equator to poles
28. Regulation of spindle length
29. Describing such a complex dynamic system
30. A systems approach to the spindle problem
31. Oligomeric motors and MTs in the test tube
32. How to build simulations
33. Microtubule-motors self organized patterns
34. Mixture of plus and minus end motors
35. What remains to be done?
36. The Importance of scale
37. Symmetry breaking and spindle assembly
38. Spindle assembly and the emergence of "function"
39. Kant's concept
40. Acknowledgements

Topics Covered

• Mitosis
• Spindle assembly
• Self-organization
• Chromosome segregation
• Microtubule dynamics
• Collective behavior of microtubule-motors systems
• Reaction diffusion processes
• Gradients of microtubule dynamics and nucleation
• The Ran system in mitosis

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009
• Archived on May 28, 2025

Financial Disclosures

• Dr. Eric Karsenti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.