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Printable Handouts
Navigable Slide Index
- Introduction
- The mitotic spindle of animal cells
- Microtubule function throughout cell cycle
- Microtubules are highly dynamic during mitosis
- Dynamics of an animal cell spindle
- A plant cell spindle
- Spindle questions
- Models of spindle assembly (1)
- The notion of cytoplasmic state
- Models of spindle assembly (2)
- The frog egg extract system
- Global regulation of microtubule dynamics
- CDK1 and microtubule tip binding proteins network
- Local microtubule nucleation around chromosomes
- Local stabilization around chromosomes
- Bipolarity and metaphase plate assembly
- Signaling pathway for the microtubule system
- Model of the Ran system
- Calculating spatio-temporal evolution
- Multiple gradients of signaling molecules
- Short and long range effects of signaling gradients
- TPX2 dependent local microtubule nucleation
- CDK11 required for centrosomal spindle bipolarity
- How microtubules organize into a bipolar array?
- Motor-dependent bipolar spindle assembly
- Spindle self-organization with centrosomes
- Tubulin fluxes from equator to poles
- Regulation of spindle length
- Describing such a complex dynamic system
- A systems approach to the spindle problem
- Oligomeric motors and MTs in the test tube
- How to build simulations
- Microtubule-motors self organized patterns
- Mixture of plus and minus end motors
- What remains to be done?
- The Importance of scale
- Symmetry breaking and spindle assembly
- Spindle assembly and the emergence of "function"
- Kant's concept
- Acknowledgements
Topics Covered
- Mitosis
- Spindle assembly
- Self-organization
- Chromosome segregation
- Microtubule dynamics
- Collective behavior of microtubule-motors systems
- Reaction diffusion processes
- Gradients of microtubule dynamics and nucleation
- The Ran system in mitosis
Talk Citation
Karsenti, E. (2009, April 30). Bipolar spindle assembly [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 4, 2024, from https://doi.org/10.69645/BXJU9276.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Eric Karsenti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.