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1. Introduction
2. The mitotic spindle of animal cells
3. Microtubule function throughout cell cycle
4. Microtubules are highly dynamic during mitosis
5. Dynamics of an animal cell spindle
6. A plant cell spindle
7. Spindle questions
8. Models of spindle assembly (1)
9. The notion of cytoplasmic state
10. Models of spindle assembly (2)
11. The frog egg extract system
12. Global regulation of microtubule dynamics
13. CDK1 and microtubule tip binding proteins network
14. Local microtubule nucleation around chromosomes
15. Local stabilization around chromosomes
16. Bipolarity and metaphase plate assembly
17. Signaling pathway for the microtubule system
18. Model of the Ran system
19. Calculating spatio-temporal evolution
20. Multiple gradients of signaling molecules
21. Short and long range effects of signaling gradients
22. TPX2 dependent local microtubule nucleation
23. CDK11 required for centrosomal spindle bipolarity
24. How microtubules organize into a bipolar array?
25. Motor-dependent bipolar spindle assembly
26. Spindle self-organization with centrosomes
27. Tubulin fluxes from equator to poles
28. Regulation of spindle length
29. Describing such a complex dynamic system
30. A systems approach to the spindle problem
31. Oligomeric motors and MTs in the test tube
32. How to build simulations
33. Microtubule-motors self organized patterns
34. Mixture of plus and minus end motors
35. What remains to be done?
36. The Importance of scale
37. Symmetry breaking and spindle assembly
38. Spindle assembly and the emergence of "function"
39. Kant's concept
40. Acknowledgements

Topics Covered

• Mitosis
• Spindle assembly
• Self-organization
• Chromosome segregation
• Microtubule dynamics
• Collective behavior of microtubule-motors systems
• Reaction diffusion processes
• Gradients of microtubule dynamics and nucleation
• The Ran system in mitosis

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Dr. Eric Karsenti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.