• Co-ordination of G1 Progression
• 37 min
  1. START control in yeast

  • Prof. Curt Wittenberg
• 33 min
  2. The pRB/E2F pathway

  • Prof. Jacqueline Lees
• 35 min
  3. Cell cycle control by the ubiquitin system in mammals

  • Prof. Michele Pagano
• Chromosome Duplication
• 47 min
  4. Replication licensing

  • Prof. Julian Blow
• 51 min
  5. Initiation of DNA replication

  • Prof. Bruce Stillman
• 48 min
  6. Regulation of replication fork progression and stability

  • Dr. Luis Aragón
• 35 min
  7. Nucleosome assembly during DNA replication

  • Dr. Alain Verreault
• Preparing for Mitosis
• 27 min
  8. Sister chromatid cohesion: simple concept, complex reality

  • Prof. Douglas Koshland
• 50 min
  9. Mitotic chromosome condensation

  • Prof. Andrew Belmont
• 33 min
  10. Centrosome duplication and separation in animal cells

  • Prof. Andrew Fry
• Spindle Assembly and Chromosome Segregation
• 30 min
  11. Bipolar spindle assembly

  • Dr. Eric Karsenti
• 54 min
  12. Chromosome bi-orientation in yeast

  • Prof. Mike Stark
  • Prof. Tomo Tanaka
• 43 min
  13. Regulation of mammalian cell division by the chromosomal passenger complex

  • Dr. Susanne Lens
• Mitotic Exit and Cytokinesis
• 39 min
  14. Cleavage furrow formation and ingression during animal cytokinesis

  • Dr. Pier Paolo D'Avino
• Checkpoints Governing Cell Cycle Progression
• 34 min
  15. The DNA damage response

  • Dr. Vincenzo Costanzo
• 54 min
  16. The spindle checkpoint

  • Dr. Kevin Hardwick
• 27 min
  17. Spindle movement and checkpoint control during mitosis in yeast

  • Prof. John Cooper
• 43 min
  18. The G2/M transition

  • Prof. Dr. René Medema
• The Cell Cycle in Development and Cancer
• 62 min
  19. Mouse models to investigate cell cycle and cancer

  • Dr. Philipp Kaldis
• 18 min
  20. Cell cycle: a complex network of signals regulating cell proliferation

  • Prof. Antonio Giordano
• 40 min
  21. Drug discovery and target validation in the p53 pathway

  • Prof. Sir David Lane
• 30 min
  22. Role and regulation of Cdk inhibitors in development and cancer

  • Prof. Martine Roussel
• 48 min
  23. The kinetochore as a target for the development of mitosis specific anti-cancer drugs

  • Dr. Tim Yen
• 47 min
  24. The Myc transcription factor network

  • Prof. Robert N. Eisenman
• Meiosis: A Specialized Cell Cycle
• 58 min
  25. Recombination and the formation of chiasmata in meiosis

  • Prof. Matthew Whitby
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  26. Geometric regulation of kinetochore orientation

  • Prof. Yoshinori Watanabe

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The centrosome discovery
3. Centrosome function
4. Centrosome is the primary MTOC of an animal cell
5. Microtubule nucleation
6. Gamma-tubulin ring complexes
7. Centrosomes and the interphase microtubuli
8. Centrosomes and the bipolar mitotic spindle
9. Microtubules of the mitotic spindle
10. Centrosomes and ciliogenesis
11. Essential and non-essential centrosome functions
12. Centrosome structure
13. Centrosomes composition: centrioles and PCM
14. Centrioles and basal bodies
15. The centrosome duplication cycle
16. Fluorescence image of cell in interphase
17. Fluorescence image of cell in mitosis
18. Fluorescence image of cell in cytokinesis
19. The importance of centrosome duplication
20. Centrosome duplication coordinated with cell cycle
21. Regulation of centrosome duplication
22. Key events in the centrosome duplication cycle
23. Two pathways for centrosome duplication
24. Molecular control of templated centriole duplication
25. Proteins involved in templated centriole duplication
26. Coordinating centriole duplication, DNA replication
27. De novo basal body/centriole formation pathways
28. Uncoupling centrosome duplication from cell cycle
29. Formation of multipolar spindles
30. Regulation of centrosome separation
31. Intercentriolar linker links interphase centrosomes
32. Cell cycle dependent centrosome cohesion
33. Molecular components of the intercentriolar linker
34. Consequence of centrosome separation defects
35. Centrosomes in cancer cells
36. Supernumerary centrosomes and cancer cells
37. Supernumerary centrosomes in cultured cells
38. Centrosome defects in tumours
39. Aneuploidy and chromosome instability
40. How do cancer cells acquire multiple centrosomes
41. Fates of cells with supernumerary centrosomes
42. Summary
43. Acknowledgments

Topics Covered

• The centrosome as a microtubule organizing centre
• Microtubule nucleation
• Mitotic spindle organization
• Centrosomes and ciliogenesis
• Centrosome structure and composition
• The centrosome duplication cycle
• Regulation of centrosome duplication
• Centriole formation pathways
• Centriolar cohesion
• Regulation of centrosome separation
• Centrosome overduplication in cancer cells
• Aneuploidy and chromosome instability
• Models for the acquisition of supernumerary centrosomes

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Andrew Fry has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.