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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- The centrosome discovery
- Centrosome function
- Centrosome is the primary MTOC of an animal cell
- Microtubule nucleation
- Gamma-tubulin ring complexes
- Centrosomes and the interphase microtubuli
- Centrosomes and the bipolar mitotic spindle
- Microtubules of the mitotic spindle
- Centrosomes and ciliogenesis
- Essential and non-essential centrosome functions
- Centrosome structure
- Centrosomes composition: centrioles and PCM
- Centrioles and basal bodies
- The centrosome duplication cycle
- Fluorescence image of cell in interphase
- Fluorescence image of cell in mitosis
- Fluorescence image of cell in cytokinesis
- The importance of centrosome duplication
- Centrosome duplication coordinated with cell cycle
- Regulation of centrosome duplication
- Key events in the centrosome duplication cycle
- Two pathways for centrosome duplication
- Molecular control of templated centriole duplication
- Proteins involved in templated centriole duplication
- Coordinating centriole duplication, DNA replication
- De novo basal body/centriole formation pathways
- Uncoupling centrosome duplication from cell cycle
- Formation of multipolar spindles
- Regulation of centrosome separation
- Intercentriolar linker links interphase centrosomes
- Cell cycle dependent centrosome cohesion
- Molecular components of the intercentriolar linker
- Consequence of centrosome separation defects
- Centrosomes in cancer cells
- Supernumerary centrosomes and cancer cells
- Supernumerary centrosomes in cultured cells
- Centrosome defects in tumours
- Aneuploidy and chromosome instability
- How do cancer cells acquire multiple centrosomes
- Fates of cells with supernumerary centrosomes
- Summary
- Acknowledgments
Topics Covered
- The centrosome as a microtubule organizing centre
- Microtubule nucleation
- Mitotic spindle organization
- Centrosomes and ciliogenesis
- Centrosome structure and composition
- The centrosome duplication cycle
- Regulation of centrosome duplication
- Centriole formation pathways
- Centriolar cohesion
- Regulation of centrosome separation
- Centrosome overduplication in cancer cells
- Aneuploidy and chromosome instability
- Models for the acquisition of supernumerary centrosomes
Talk Citation
Fry, A. (2009, April 30). Centrosome duplication and separation in animal cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 28, 2024, from https://hstalks.com/bs/1260/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Andrew Fry has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.