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Navigable Slide Index

1. Introduction
2. E2F transcription factors control cell cycle entry
3. E2f controls transcription of cell cycle regulators
4. Inhibitory and mitogenic signals
5. The pocket proteins: pRB family of proteins
6. Differential roles of the pocket proteins (1)
7. Different pocket proteins bind different E2Fs
8. E2F targets regulated by distinct E2F complexes
9. Rb mutant mice
10. Inhibition of E2Fs is key to pRB's activity
11. Differential roles of the pocket proteins (2)
12. E2Fs can induce apoptosis and senescence
13. Role of pRB-E2F in DNA damage response
14. pRB-E2F in DNA damage response - experiment 1
15. pRB-E2F in DNA damage response - experiment 2
16. pRB contributes to activation of apoptosis
17. pRB's apoptosis induction in vivo
18. The pRB/E2F proliferation pathway
19. Mutations in the pRB/E2F pathway (1)
20. Mutations in the pRB/E2F pathway (2)
21. Acknowledgements

Topics Covered

• The E2F transcription factors control cell cycle entry
• The pRB/E2F pathway
• pRB and E2F are both families of proteins
• Differential roles of the pocket proteins
• Repression and activation of E2F target genes is regulated by distinct E2F complexes
• Rb mutant mice
• Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity
• The activating E2Fs can also induce apoptosis and senescence genes in tumor cells
• Role of pRB-E2F in DNA damage response
• pRB contributes to the activation of pro-apoptotic genes in response to DNA damage

Links

Series:

• The Cell Division Cycle

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on April 30, 2009

Financial Disclosures

• Prof. Jacqueline Lees has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.