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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- Control of cell proliferation
- The budding yeast: Saccharomyces cerevisiae
- Why yeast?
- The budding yeast life cycle
- Placement of START in the cell cycle
- Observing START
- The concept of "START" - The G1 checkpoint
- Genetic characterization of START
- Interdependency of Cdk1 with START regulators
- Cyclin-dependent protein kinase (CDK)
- The cyclin/CDK cycle
- G1 cyclin/CDK is essential for START
- The role of CDK in START
- Periodic expression of Far1 and cyclins
- Cell cycle regulators accumulation in G1
- The molecular correlate of START
- G1-specific transcription
- Phosphorylation of Whi5 by Cln3
- Repression of MBF and SBF as cells exit G1
- Conservation of G1-specific transcription regulators
- G1-specific gene expression and human cancer
- The molecular determinant of START - summary
- Physiological regulators of START
- Mating generates diploid cells from haploid cells
- Cells of opposite mating types can conjugate
- Responses elicit by mating pheromone cascade
- Mating pheromone signaling pathway
- Far1 activation by mating pheromones
- Regulation of START by other stimuli
- Control of START by cell size
- The molecular basis for the Sizer and Timer
- Possible signals for achieving minimum cell size
- Summary
- Related reading
Topics Covered
- Control of cell proliferation
- The budding yeast: Saccharomyces cerevisiae
- Why yeast?
- The budding yeast life cycle
- Placement of START in the cell cycle
- Observing START
- The G1 Checkpoint
- Genetic characterization of START
- Interdependency of Cdk1 with other regulators of START
- Cyclin-Dependent Protein Kinase (CDK)
- The cyclin/CDK cycle
- G1 cyclin/CDK is essential for START
- The role of CDK in START
- Cell cycle dependent expression of Far1 and cyclins
- Periodic accumulation of yeast cell cycle regulators
- The molecular correlate of START
- G1-specific transcription
- G1-specific gene expression and human cancer
- The molecular determinant of START
- Physiological regulators of START
- Mating generates diploid cells from two haploid cells
- Cells of opposite mating types can conjugate
- Stimulation of the mating pheromone cascade elicits three primary responses
- Mating pheromone signaling pathway
- Mating pheromone promotes G1 phase arrest by activating the Cln/CDK inhibitor, Far1
- Regulation of START by other stimuli
- Control of START by cell size
- The molecular basis for the sizer and timer
- What is the signal for achievement of minimum cell size?
Talk Citation
Wittenberg, C. (2009, April 30). START control in yeast [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1253/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Curt Wittenberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.