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1. Epigenetically mediated gene silencing
2. Process of DNA methylation
3. Altered chromatin status in cancer
4. Familial cancer genes
5. Chromatin composition
6. Screening the cancer genome
7. Vogalstein paradigm
8. Re-activated hypermethylated genes
9. Hypothesis-early stage epigenetic gene silencing
10. Epigenetic & genetic interaction in tumorigenesis
11. sFRP genes - what are they?
12. SFRP hypermethylation and CRC progression
13. Epigenetic silencing of SFRPs in CRC
14. Concept of cancer pathway addiction
15. Collaboration in early colon tumorigenesis
16. Heretical hypothesis
17. Re-activated hypermethylated genes
18. Screening the cancer genome
19. HIC-1 is a candidate tumor suppressor gene
20. HIC-1 hypermethylation in human cancer
21. Targeted disruption of mouse Hic-1 gene
22. Hic-1 as a tumor suppressor in mouse models
23. Epigenetic and genetic interactions
24. The full activities if HIC-1
25. Properties of SIRT1
26. Paradigm summary for HIC-1 P53 interaction
27. Hypothesis review
28. Translational implications

Topics Covered

• Introduction to epigenetic changes in cancer
• defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer
• defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes
• defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer
• outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis
• defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis
• discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cancer
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Oncology

Talk Citation

Baylin, S. (2007, October 1). Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/VRTX2257.
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Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Stephen Baylin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.