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Printable Handouts
Navigable Slide Index
- Introduction
- Regulatory documents
- Relevant literature
- The process of absorption in the GI tract
- Schematic of the process of absorption in the GI tract
- Dissolution testing requirements
- Discriminative method
- Study the substance’s properties
- The Biopharmaceutics Classification System (BCS)
- Biopharmaceutical solubility (1)
- Equipment
- Biopharmaceutical solubility: High solubility
- Biopharmaceutical solubility: Indapamide
- Biopharmaceutical solubility: Literature data (1)
- Biopharmaceutical solubility: Literature data (2)
- Biopharmaceutical solubility (2)
- Sink conditions
- FDA dissolution database
- FDA dissolution database: Dissolution methods
- Who takes part in the methodology development process?
- Choosing equipment
- Potential issues with the paddle apparatus
- Cone formation
- Examples of sinkers
- Choosing equipment: Rotating basket
- BCS 1st class (1)
- BCS 1st class (2)
- BCS 2nd class
- BCS 2nd class: pH-independent substances
- BCS 2nd class: Dissolution medium of pH higher than 7.5
- BCS 2nd class: Undesirable choice
- BCS 2nd class: The best choice
- BCS 3rd and 4th classes
- Sources of variability
- Degassing
- Summary
- Acknowledgements and disclosures
Topics Covered
- Absorption in the GI
- Dissolution testing requirements
- Discriminative method
- The Biopharmaceutics Classification System (BCS)
- Biopharmaceutical solubility
- Sink condition
- FDA dissolution database
Links
Categories:
External Links
Talk Citation
Shohin, I.E. (2025, December 31). Dissolution testing: methodology development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 31, 2025, from https://doi.org/10.69645/KGTJ4889.Export Citation (RIS)
Publication History
- Published on December 31, 2025
Financial Disclosures
- CEO of the Center of Pharmaceutical Analytics (CPHA).