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Printable Handouts
Navigable Slide Index
- Introduction
- Sir William Osler
- Variability in human pain sensitivity - experimental
- Is variability in human pain sensitivity real?
- Variability in human pain sensitivity - clinical
- Variability in clinical morphine analgesia
- Nature and nurture
- Heritability of pain-related traits
- Study of 49degrees C tail-withdrawal latency variability
- Classification and regression tree (CART) results
- G, E and GxE in the tail-withdrawal test
- "Pain genes"
- The pain genes database
- Genes responsible for monogenic pain disorders
- Finding pain variability genes - two choices
- Genes potentially associated with pain states
- The problem with association studies
- Finding pain variability genes - other choices
- Fancy mice: origin of inbred strains
- Twelve inbred mouse strains
- Inbred mice responses to nociceptive assays
- Correlations among pain tests in inbred mice
- Genetic "clusters" of pain tests
- Qualitative strain differences in pain
- Differences in pain tests and pain processing
- Statistically confirmed pain-relevant QTLs
- MC1Rs and pain - mice and humans
- Candidate genes and positional cloning
- The formalin test
- Responses of inbred mice to 5% formalin
- Two formalin test QTLs: Nociq1and Nociq2
- Haplotype mapping
- Haplotype mapping of chrom. 9 formalin test QTL
- Atp1b3
- Atp1b3 differential expression in two mice strains
- siRNA knockdown of Atp1b3
- Take-away messages
- Acknowledgments
Topics Covered
- Variability in pain sensitivity and analgesia
- Heritability of pain
- Genetic and environmental contributions to pain
- Pain genes
- Monogenic pain disorders
- Association studies
- Inbred mouse strains and strain differences
- Genetic correlations among pain phenotypes
- Quantitative trait loci (QTLs)
- Melanocortin-1 receptors and pain
- Formalin test QTLs
- Haplotype mapping
- Atp1b3 and formalin pain
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Talk Citation
Mogil, J.S. (2009, January 26). The genetics of pain [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/IYUH6172.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jeffrey S. Mogil has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.