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1. Introduction
2. Migraine headaches
3. Trigeminovascular system
4. Cortical spreading depression (CSD)
5. Factors modulating CSD
6. Cardinal features of CSD
7. CSD imaging
8. MR pertubation vs. CSD blood flow (rodent)
9. Mechanism for CSD initiation and propagation
10. Genetic mutations and CSD
11. Familial hemiplegic migraine: types-1,2, and 3
12. FHM-1
13. Mutations of Cav2.1-alpha1A in humans and mice
14. Threshold for evoking CSD in tg mutant mice
15. Generation of R192Q and S218L mutant mice
16. CSD frequency in R192Q KI mouse
17. Behavior of WT vs. R192Q mutant mouse
18. Phenotype of S218L mutation in humans
19. Representative CSD tracings
20. Behavior after CSD: S218L
21. Striatal recordings
22. Mutated genes: FHM-2
23. Mechanism for CSD generation in FHM-2
24. FHM-3
25. Sex hormones and CSD
26. CSD in R192Q KI mouse: male vs. female
27. CSD: modulation by sex steroids
28. Prophylactic drugs and CSD
29. Prophylaxis of migraine
30. Prophylactic drugs decrease CSD susceptibility
31. Drug impact on electrically evoked CSD
32. Time response
33. Hypoxic stress and CSD
34. NADH during spreading depression
35. Summary
36. Acknowledgements

Topics Covered

• Migraine headache
• Pathophysiology and importance of cortical spreading depression (CSD)
• Evidence for CSD in human cortex
• Susceptibility to CSD as modified by genetic mutations
• Susceptibility to CSD as modified by ovarian hormones
• Prophylactic drugs render the brain resistant to CSD
• Hypoxia insult during the propagation of CSD

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Moskowitz, M. (2009, January 26). Cortical spreading depression and translational mechanisms in migraine headache [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/GJWR1037.
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Publication History

• Published on January 26, 2009

Financial Disclosures

• Prof. Michael Moskowitz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.