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Printable Handouts
Navigable Slide Index
- Introduction
- Pain: concept and early anatomy
- Enabling technology for spinal anesthesia
- James Leonard Corning (1855-1923)
- Bier and Hildebrand: intrathecal drug delivery
- Rapid evolution of spinal anesthetic delivery in US
- Early appreciation of risks of spinal anesthesia
- Modulation of spinal processing
- Targeting drugs at spinal function
- Other systems which regulate spinal afferent input
- Pain selectively diminished by spinal opioids
- Spinal mu\delta opioid action
- Targeting drugs at spinal function (1)
- Targeting drugs at spinal function (2)
- Targeting drugs at spinal function (3)
- Rat as a surrogate for drugs activity in humans
- Spinal analgesics: animal and human pain
- Safety of spinal drugs
- Safety concerns of spinal drugs
- Early safety issues with spinal anesthetic
- Classes of spinal toxicity
- Intrathecal lidocaine and toxicity
- Spinal toxicity: root
- Spinal toxicity: parenchyma
- Spinal toxicity: meningeal
- Human intrathecal morphine: granuloma
- Morphine and granulomas: concentration vs. dose
- There are no safe drugs, only safe doses
- Safety of spinal drugs: summary (1)
- Safety of spinal drugs: summary (2)
- Future and neuraxial drug delivery
- The canary tale
Topics Covered
- Pain: concepts and early anatomy
- Role of sensory nerves and spinal cord
- Enabling technology for spinal anesthesia
- Rapid evolution of spinal anesthetic delivery in the US
- Early appreciation of risks of spinal anesthesia
- Modulation of spinal processing
- Targeting drugs at spinal function
- Other systems which regulate spinal afferent transmission
- Pain selectively diminished by spinal opioids
- Spinal mu/delta opioid action
- Spinal analgesics: animal and human pain
- Safety of spinal drugs
- Early safety issues with spinal anesthetic
- Classes of spinal toxicity
- Intrathecal lidocaine and toxicity
- Spinal toxicity: root, parenchyma, meningeal
- Human intrathecal morphine: granuloma
- IT morphine and granulomas concentration vs. dose
- Future and neuraxial drug delivery
Links
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Talk Citation
Yaksh, T. (2009, January 26). Spinal drug delivery: technology, biology and toxicology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 28, 2021, from https://hstalks.com/bs/1133/.Publication History
Financial Disclosures
- Prof. Tony Yaksh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Spinal drug delivery: technology, biology and toxicology
Published on January 26, 2009
48 min