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1. Introduction
2. Pain: concept and early anatomy
3. Enabling technology for spinal anesthesia
4. James Leonard Corning (1855-1923)
5. Bier and Hildebrand: intrathecal drug delivery
6. Rapid evolution of spinal anesthetic delivery in US
7. Early appreciation of risks of spinal anesthesia
8. Modulation of spinal processing
9. Targeting drugs at spinal function
10. Other systems which regulate spinal afferent input
11. Pain selectively diminished by spinal opioids
12. Spinal mu\delta opioid action
13. Targeting drugs at spinal function (1)
14. Targeting drugs at spinal function (2)
15. Targeting drugs at spinal function (3)
16. Rat as a surrogate for drugs activity in humans
17. Spinal analgesics: animal and human pain
18. Safety of spinal drugs
19. Safety concerns of spinal drugs
20. Early safety issues with spinal anesthetic
21. Classes of spinal toxicity
22. Intrathecal lidocaine and toxicity
23. Spinal toxicity: root
24. Spinal toxicity: parenchyma
25. Spinal toxicity: meningeal
26. Human intrathecal morphine: granuloma
27. Morphine and granulomas: concentration vs. dose
28. There are no safe drugs, only safe doses
29. Safety of spinal drugs: summary (1)
30. Safety of spinal drugs: summary (2)
31. Future and neuraxial drug delivery
32. The canary tale

Topics Covered

• Pain: concepts and early anatomy
• Role of sensory nerves and spinal cord
• Enabling technology for spinal anesthesia
• Rapid evolution of spinal anesthetic delivery in the US
• Early appreciation of risks of spinal anesthesia
• Modulation of spinal processing
• Targeting drugs at spinal function
• Other systems which regulate spinal afferent transmission
• Pain selectively diminished by spinal opioids
• Spinal mu/delta opioid action
• Spinal analgesics: animal and human pain
• Safety of spinal drugs
• Early safety issues with spinal anesthetic
• Classes of spinal toxicity
• Intrathecal lidocaine and toxicity
• Spinal toxicity: root, parenchyma, meningeal
• Human intrathecal morphine: granuloma
• IT morphine and granulomas concentration vs. dose
• Future and neuraxial drug delivery

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Medicine
• Methods
• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Yaksh, T. (2009, January 26). Spinal drug delivery: technology, biology and toxicology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 19, 2019, from https://hstalks.com/bs/1133/.

Publication History

• Published on January 26, 2009