Please wait while the transcript is being prepared...
0:00
Hello, I'm Dr. Philip Harvey,
Leonard M. Miller
Professor of psychiatry
and behavioral sciences at
the University of Miami
Miller School of Medicine.
Today, we're going
to be talking about
self-knowledge and
schizophrenia:
importance, characteristics,
and treatment.
0:17
I have some disclosures
to reveal to you.
I've consulted with
drug and device makers
targeting cognitive
impairments and
negative symptoms
in schizophrenia.
The data presented
in this lecture
were all collected with
NIMH-funded grants,
and the numbers
are on the slide.
These grants were awarded
both to me and to
several of my close
collaborators,
including Amy Pinkham,
Colin Depp, and
Thomas Patterson.
0:42
There are multiple domains of
symptoms in schizophrenia.
They include psychotic symptoms,
such as delusions
and hallucinations,
communication disorders,
negative symptoms, and
cognitive impairment.
These are the classic
symptoms described by
the early investigators who
were looking at schizophrenia,
then known as dementia praecox.
These are long-standing,
well-understood domains
of impairment that we see.
1:09
But there's one thing
that these domains share,
and that is they share
common features.
There are challenges in
self-assessment associated
with all of these domains.
Some symptoms arise
completely from
what appears to be
systematic misperceptions.
Hallucinations are
voices that seem real
but aren't really present.
Delusions are
self-generated ideas
that are resistant
to disconfirmation.
Cognitive functioning is
commonly misestimated,
as are everyday
functional abilities.
Mood states are
reported incongruently.
Communication disorders
may also arise from
challenges in
discriminating the source
and status of information.
We're going to talk about
all these different features
as we go forward today.
Most importantly, what we
see in schizophrenia is
