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1. Epigenetic regulation of phenotype
2. What is epigenetics?
3. Example of variagation in mice
4. Transgene expression is sometimes variegated
5. Variegating phenotype in the eye
6. Current important questions in the field
7. Epigenetic modifications
8. Epigenetic modification questions
9. When are the marks laid down?
10. Where are the marks laid down ?
11. Agouti viable yellow (Avy)
12. Transgenerational epigenetic inheritance at Avy
13. Information can be inherited from parent to offspring
14. When are the marks cleared and re-established?
15. Methylation at the Avy allele in sperm
16. Avy allele is reprogrammed in early development
17. How many metastable epialleles are there?
18. Can environment influence these processes?
19. Epigenetics and environment - maternal licking
20. Epigenetic state is a record of environmental history
21. Can genetic modifiers shift penetrance at Avy ?
22. Enu screen for genes involved
23. Flow cytometric analysis of transgene expression
24. ENU mutagenesis to find genetic modifiers
25. Dominate and recessive mutations
26. Review of mapping progress
27. What has the screen told us
28. Acknowledgements

Topics Covered

• When does epigenetic reprogramming during the transfer of DNA between parents and their offspring occur, in the gametes or in early development?
• inheritance of epigenetic marks can occur, meaning that information other than DNA sequence can be passed on from parent to offspring
• the influence of parental environmental history on an individual's epigenetic state
• does epigenetic inheritance have an adaptive value?
• could epigenetic state be used to give a better estimate of disease risk?

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Prof. Emma Whitelaw has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.