Registration for a live webinar on 'Phasing Out Animal Testing: A New Era for Pharmaceutical Innovation' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Epidemiology and Risk Factors
-
1. Coronary heart disease epidemiology: global context for a new genetic understanding
- Prof. Harry Hemingway
-
2. Cardiovascular risk factors
- Dr. Michal Vrablik
-
3. Lipoproteins
- Prof. Arnold von Eckardstein
-
4. Thrombotic risk factors for cardiovascular disease
- Prof. Gordon Lowe
-
5. Lipoprotein(a)
- Dr. Jaimini Cegla
- Biology of Coronary Heart Disease
-
6. Plaque rupture
- Prof. Petri Kovanen
-
7. Transcription factors and complex disease development
- Dr. Ines Pineda-Torra
-
8. Animal models to explore cardiovascular disease
- Prof. Martin Merkel
- Treatment
-
9. Diagnosis and treatment of dyslipidemias
- Prof. Anton Stalenhoef
-
10. Key drug discovery challenges in cardiovascular medicine
- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Genetics
-
11. Moving from GWAS hits to functional variants
- Prof. Steve Humphries
-
12. Heart disease genes and SNPs
- Prof. Steve Humphries
-
13. Familial hypercholesterolaemia: genetic causes and treatment
- Prof. Steve Humphries
-
14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes
- Prof. Steve Humphries
-
16. Genetics of cardiovascular disease
- Prof. Philippa Talmud
-
17. The genetics of CHD: moving research findings into patient benefit
- Prof. Steve Humphries
-
19. The genetics of abdominal aortic aneurysm
- Dr. Seamus Harrison
-
20. Genome scans for hypertension
- Prof. Patricia Munroe
-
21. Telomeres and cardiovascular disease
- Dr. Jess Buxton
-
23. Genetics of hypertrophic cardiomyopathy (HCM)
- Dr. Petros Syrris
- Archived Lectures *These may not cover the latest advances in the field
-
24. Gene-environment interaction and oxidative stress in cardiovascular disease
- Dr. Jeffrey Stephens
-
25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency
- Dr. Jan Albert Kuivenhoven
-
26. Cardiovascular diseases: from epidemiology to nutritional interventions
- Dr. Antonis Zampelas
-
27. Genetic testing for CHD risk: fact or fiction?
- Prof. Steve Humphries
-
28. Pharmacogenetics: progress, pitfalls and clinical potential
- Prof. Steve Humphries
-
29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD
- Prof. Steve Humphries
-
30. Lipid metabolism
- Dr. Ulrike Beisiegel
Printable Handouts
Navigable Slide Index
- Introduction
- Cardiovascular disease
- Monogenic form of common disorder
- Single gene disorders and cardiovascular disease
- Genetic basis of the common form of CHD
- Polygenic form of common disorder
- Common forms of cardiovascular disease
- CHD study design
- Candidate genes or whole genome
- Genome wide association studies
- Case and control
- SNPs on chromosome 9 associated with CHD
- A new dawn for genetics of complex disorders
- A new dawn for genetics of complex traits
- Allele frequency and effect size (1)
- Allele frequency and effect size (2)
- Genetic architecture of common disease
- Translation of genomic discoveries
- Genotype knowledge predicting risk of disease
- Potential advantages of genetic tests
- The problem
- Hypothetical population and a perfect test
- A perfect test (cont.)
- A less than perfect test (1)
- A less than perfect test (2)
- A genetic test (1)
- A genetic test (2)
- Rare, high penetrance mut. - population screening
- Rare, high penetrance mut. - family screening
- Another genetic test (1)
- Another genetic test (2)
- Apolipoprotein E as a genetic marker
- Predictive genetic screening for CHD (1)
- Predictive genetic screening for CHD (2)
- Multiple risk alleles
- Genetic profiling perform poorly as a discriminator
- Genotype and prediction of CHD
- Translation of genomic discoveries
- Unique properties of genotype
- Novel biomarkers and cardiovascular disease
- Cardiovascular disease and the translational gap
- Non-causal explanations
- Investigating causal role through experimentation
- Non-experimental studies in humans
- "The cholesterol myth"
- Identification and validation of a "drug-target"
- The final arbiter of the validity - RCT in humans
- Observational studies and RCTs of statin drugs
- Attrition of new molecular entities
- "Nature's randomised trials"
- Homocysteine and stroke
- Possible explanations of this observation
- Difference in Hcy according to genotypes
- Random allocation of MTHFR genotypes
- Genotype, risk marker and event rate (1)
- Genotype, risk marker and event rate (2)
- Observed genetic effect and observational studies
- LDL-C and CHD: Mendelian randomisation study
- Mendelian randomisation: a historical perspective
- Conclusion
Topics Covered
- Ischaemic heart disease
- Valvular heart disease
- Heart muscle disease
- Monogenic form of common disorder
- Single gene disorders and cardiovascular disease
- Mutation both necessary and sufficient to lead to disease
- Genetic basis of the common form of CHD
- Polygenic form of common disorder
- Complex disorders
- Study design
- Candidate genes or whole genome
- Genome-wide association studies
- A new dawn for genetics of complex disorders and traits
- Relationship between allele frequency and effect size
- Genetic architecture of common disease
- Translation of genomic discoveries
- Potential advantages of genetic tests
- Predictive genetic screening for CHD
- Low penetrance polymorphisms
- Multiple risk alleles
- Why genetic testing might perform poorly as a discriminatory test
- Genotype and prediction of CHD
- Using genotype to gain insight into the causes of CHD
- Unique properties of genotype
- Novel biomarkers and CVD
- CVD and the translational gap
- Attrition of new molecular entities
- Association of a quantitative trait with clinical events may have a non-causal explanation
- Investigating causal role through experimentation
- Validation of a drug target requires experimentation
- Non-experimental studies in humans
- The "cholesterol myth"
- Identification and validation of a "drug-target"
- The final arbiter of the validity of the therapeutic target is the RCT in humans
- Nature's randomized trials
- Homocysteine and stroke
- Triangulation between genotype, biochemical risk marker and event rate
- Mendelian randomization
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hingorani, A. (2008, December 18). Translational applications of cardiovascular genomics: opportunities and challenges [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/GAID3730.Export Citation (RIS)
Publication History
- Published on December 18, 2008
Financial Disclosures
- Dr. Aroon Hingorani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Hide