• Epidemiology and Risk Factors
• 23 min
  1. Coronary heart disease epidemiology: global context for a new genetic understanding

  • Prof. Harry Hemingway
• 44 min
  2. Cardiovascular risk factors

  • Dr. Michal Vrablik
• 65 min
  3. Lipoproteins

  • Prof. Arnold von Eckardstein
• 39 min
  4. Thrombotic risk factors for cardiovascular disease

  • Prof. Gordon Lowe
• 20 min
  5. Lipoprotein(a)

  • Dr. Jaimini Cegla
• Biology of Coronary Heart Disease
• 42 min
  6. Plaque rupture

  • Prof. Petri Kovanen
• 56 min
  7. Transcription factors and complex disease development

  • Dr. Ines Pineda-Torra
• 39 min
  8. Animal models to explore cardiovascular disease

  • Prof. Martin Merkel
• Treatment
• 26 min
  9. Diagnosis and treatment of dyslipidemias

  • Prof. Anton Stalenhoef
• 31 min
  10. Key drug discovery challenges in cardiovascular medicine

  • Dr. Dan Swerdlow
  • Dr. Michael V. Holmes
• Genetics
• 50 min
  11. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 51 min
  12. Heart disease genes and SNPs

  • Prof. Steve Humphries
• 39 min
  13. Familial hypercholesterolaemia: genetic causes and treatment

  • Prof. Steve Humphries
• 22 min
  14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes

  • Prof. Steve Humphries
• 28 min
  15. Familial hypercholesterolaemia: case studies, universal screening and novel mutations

  • Prof. Steve Humphries
• 52 min
  16. Genetics of cardiovascular disease

  • Prof. Philippa Talmud
• 54 min
  17. The genetics of CHD: moving research findings into patient benefit

  • Prof. Steve Humphries
• 35 min
  18. Mendelian randomisation: using genetics to determine causality

  • Dr. Tina Shah
• 33 min
  19. The genetics of abdominal aortic aneurysm

  • Dr. Seamus Harrison
• 49 min
  20. Genome scans for hypertension

  • Prof. Patricia Munroe
• 43 min
  21. Telomeres and cardiovascular disease

  • Dr. Jess Buxton
• 33 min
  22. Translational applications of cardiovascular genomics: opportunities and challenges

  • Dr. Aroon Hingorani
• 26 min
  23. Genetics of hypertrophic cardiomyopathy (HCM)

  • Dr. Petros Syrris
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  24. Gene-environment interaction and oxidative stress in cardiovascular disease

  • Dr. Jeffrey Stephens
• 34 min
  25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency

  • Dr. Jan Albert Kuivenhoven
• 60 min
  26. Cardiovascular diseases: from epidemiology to nutritional interventions

  • Dr. Antonis Zampelas
• 45 min
  27. Genetic testing for CHD risk: fact or fiction?

  • Prof. Steve Humphries
• 35 min
  28. Pharmacogenetics: progress, pitfalls and clinical potential

  • Prof. Steve Humphries
• 50 min
  29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD

  • Prof. Steve Humphries
• 29 min
  30. Lipid metabolism

  • Dr. Ulrike Beisiegel

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Primary dyslipidemias
3. Structure of lipoproteins
4. Physicochemical properties of lipoproteins
5. Lipoprotein classes and atherosclerosis
6. Autosomal dominant hypercholesterolemia
7. Autosomal recessive hypercholesterolemia
8. Primary dyslipidemias
9. Familial hypercholesterolemia pedigree
10. Metabolic abnormality in FH
11. The attribute of sex to coronary death
12. Typical xanthomas
13. Atherosclerosis recognition by Bmode ultrasound
14. Thin intima vs. thick intima
15. Diagnosis of FH
16. Pharmacotherapy
17. Mechanism of action of statins
18. Increase in the synthesis of hepatic LDL receptors
19. Niacin
20. Dual inhibition
21. Hypolipidemic drug therapy
22. Case FH
23. Case FH: LDL-c lowering after combined treatment
24. FH - current situation
25. Tracing FH patients
26. Familial combined hyperlipidemia
27. FCH prevalence
28. 1973 FCH definition
29. FCH pedigree
30. Lipid and lipoprotein levels in FCH
31. Lipoprotein particle size
32. Associated CHD risk with an apoB increase
33. Insulin resistance in FCH
34. Values for prediction of FCH
35. Therapy FCH
36. Hypertriglyceridemia treatment
37. Familial hypertriglyceridemia
38. TG levels after treatment
39. TG concentration and production
40. Triglycerides variation in serum
41. Cholesterol and triglycerides elevated
42. Familial dysbetalipoproteienemia
43. Palmar streaks in FD
44. Tubero eruptive xanthomas in FD
45. Apolipoprotein E isoforms
46. Pedigree of index-patient and family members
47. ApoE type and frequencies in the Netherlands
48. Cholesterol levels in apoE2/E2
49. Aggravating factors
50. Lipid values in FD patients
51. Reduced penetrance
52. Clinical diagnosis
53. Secondary dyslipidemias
54. Secondary forms of HLP
55. Lipemia retinalis
56. Appearance of plasma before and after treatment

Topics Covered

• Primary dyslipidemias
• Autosomal dominant and recessive hypercholesterolemia
• Familial hypercholesterolemia
• Familial combined hyperlipidemia
• Familial hypertriglyceridemia
• Familial dysbetalipoproteinemia
• Pharmacotherapy
• Secondary dyslipidemias

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on November 24, 2008

Financial Disclosures

• Prof. Anton Stalenhoef has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.