• Epidemiology and Risk Factors
• 23 min
  1. Coronary heart disease epidemiology: global context for a new genetic understanding

  • Prof. Harry Hemingway
• 44 min
  2. Cardiovascular risk factors

  • Dr. Michal Vrablik
• 65 min
  3. Lipoproteins

  • Prof. Arnold von Eckardstein
• 39 min
  4. Thrombotic risk factors for cardiovascular disease

  • Prof. Gordon Lowe
• 20 min
  5. Lipoprotein(a)

  • Dr. Jaimini Cegla
• Biology of Coronary Heart Disease
• 42 min
  6. Plaque rupture

  • Prof. Petri Kovanen
• 56 min
  7. Transcription factors and complex disease development

  • Dr. Ines Pineda-Torra
• 39 min
  8. Animal models to explore cardiovascular disease

  • Prof. Martin Merkel
• Treatment
• 26 min
  9. Diagnosis and treatment of dyslipidemias

  • Prof. Anton Stalenhoef
• 31 min
  10. Key drug discovery challenges in cardiovascular medicine

  • Dr. Dan Swerdlow
  • Dr. Michael V. Holmes
• Genetics
• 50 min
  11. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 51 min
  12. Heart disease genes and SNPs

  • Prof. Steve Humphries
• 39 min
  13. Familial hypercholesterolaemia: genetic causes and treatment

  • Prof. Steve Humphries
• 22 min
  14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes

  • Prof. Steve Humphries
• 28 min
  15. Familial hypercholesterolaemia: case studies, universal screening and novel mutations

  • Prof. Steve Humphries
• 52 min
  16. Genetics of cardiovascular disease

  • Prof. Philippa Talmud
• 54 min
  17. The genetics of CHD: moving research findings into patient benefit

  • Prof. Steve Humphries
• 35 min
  18. Mendelian randomisation: using genetics to determine causality

  • Dr. Tina Shah
• 33 min
  19. The genetics of abdominal aortic aneurysm

  • Dr. Seamus Harrison
• 49 min
  20. Genome scans for hypertension

  • Prof. Patricia Munroe
• 43 min
  21. Telomeres and cardiovascular disease

  • Dr. Jess Buxton
• 33 min
  22. Translational applications of cardiovascular genomics: opportunities and challenges

  • Dr. Aroon Hingorani
• 26 min
  23. Genetics of hypertrophic cardiomyopathy (HCM)

  • Dr. Petros Syrris
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  24. Gene-environment interaction and oxidative stress in cardiovascular disease

  • Dr. Jeffrey Stephens
• 34 min
  25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency

  • Dr. Jan Albert Kuivenhoven
• 60 min
  26. Cardiovascular diseases: from epidemiology to nutritional interventions

  • Dr. Antonis Zampelas
• 45 min
  27. Genetic testing for CHD risk: fact or fiction?

  • Prof. Steve Humphries
• 35 min
  28. Pharmacogenetics: progress, pitfalls and clinical potential

  • Prof. Steve Humphries
• 50 min
  29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD

  • Prof. Steve Humphries
• 29 min
  30. Lipid metabolism

  • Dr. Ulrike Beisiegel

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Thrombosis and cardiovascular disease (1)
3. Illustration of thrombosis in a coronary artery
4. Deep vein thrombosis of the leg
5. Thrombosis and cardiovascular disease (2)
6. Cardiovascular and thrombotic risk factors
7. Processes in thrombosis
8. Platelets and thrombosis
9. Molecular mechanism of platelets in thrombosis
10. Platelet related risk factors
11. Common SNP's for platelet receptors and CHD
12. Role of platelets in thrombosis - summary
13. Coagulation and thrombosis
14. Coagulation cascade (1)
15. Coagulation cascade illustration (1)
16. Coagulation cascade (2)
17. Coagulation cascade illustration (2)
18. Coagulation cascade (3)
19. Coagulation cascade illustration (3)
20. Coagulation cascade (4)
21. Coagulation cascade illustration (4)
22. Roles of coagulation factors in thrombosis
23. Increased coagulation factors
24. Fibrinogen and thrombosis
25. Fibrinogen studies collaboration (FSC)
26. Fibrinogen as predictor of death
27. Fibrinogen and arterial thrombosis
28. Beta-fibrinogen SNP's and CHD
29. Fibrinogen: gene-enviorment interaction
30. Von Willebrand factor
31. Factor VII: VWF complex and thrombosis
32. VWF and risk of CHD
33. Genetics of VWF
34. Factor VII and thrombosis
35. Coagulation inhibitors and thrombosis
36. Coagulation inhibitors pathways
37. Genetic deficiency of coagulation inhibitors
38. Activated protein C resistance
39. Activated protein C resistance: gene-enviorment
40. Activated protein C resistance and CHD
41. Coagulation activation markers and thrombosis
42. Activation markers pathways
43. Fibrin D-dimer and thrombosis (1)
44. D-dimer and CHD
45. Fibrin D-dimer and thrombosis (2)
46. Other coagulation activation markers
47. Coagulation and thrombosis
48. Fibrinolysis and thrombosis (1)
49. Plasminogen activation and inhibition
50. Fibrinolysis and thrombosis (2)
51. Fibrinolysis and thrombosis (3)
52. Conclusions
53. Acknowledgements

Topics Covered

• Thrombosis: arterial and venous
• Processes in thrombosis
• Platelets
• Coagulation
• Coagulation factors
• Coagulation Inhibitors
• Coagulation activation markers
• Fibrinolysis

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic
• Haematology

Talk Citation

Publication History

• Published on November 24, 2008

Financial Disclosures

• Prof. Gordon Lowe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.