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- Epidemiology and Risk Factors
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23 min
1. Coronary heart disease epidemiology: global context for a new genetic understanding- Prof. Harry Hemingway
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44 min
2. Cardiovascular risk factors- Dr. Michal Vrablik
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65 min
3. Lipoproteins- Prof. Arnold von Eckardstein
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39 min
4. Thrombotic risk factors for cardiovascular disease- Prof. Gordon Lowe
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20 min
5. Lipoprotein(a)- Dr. Jaimini Cegla
- Biology of Coronary Heart Disease
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42 min
6. Plaque rupture- Prof. Petri Kovanen
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56 min
7. Transcription factors and complex disease development- Dr. Ines Pineda-Torra
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39 min
8. Animal models to explore cardiovascular disease- Prof. Martin Merkel
- Treatment
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26 min
9. Diagnosis and treatment of dyslipidemias- Prof. Anton Stalenhoef
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31 min
10. Key drug discovery challenges in cardiovascular medicine- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Genetics
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50 min
11. Moving from GWAS hits to functional variants- Prof. Steve Humphries
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51 min
12. Heart disease genes and SNPs- Prof. Steve Humphries
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39 min
13. Familial hypercholesterolaemia: genetic causes and treatment- Prof. Steve Humphries
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22 min
14. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes- Prof. Steve Humphries
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28 min
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52 min
16. Genetics of cardiovascular disease- Prof. Philippa Talmud
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54 min
17. The genetics of CHD: moving research findings into patient benefit- Prof. Steve Humphries
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35 min
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33 min
19. The genetics of abdominal aortic aneurysm- Dr. Seamus Harrison
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49 min
20. Genome scans for hypertension- Prof. Patricia Munroe
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43 min
21. Telomeres and cardiovascular disease- Dr. Jess Buxton
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33 min
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26 min
23. Genetics of hypertrophic cardiomyopathy (HCM)- Dr. Petros Syrris
- Archived Lectures *These may not cover the latest advances in the field
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44 min
24. Gene-environment interaction and oxidative stress in cardiovascular disease- Dr. Jeffrey Stephens
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34 min
25. Gene therapy as a therapeutic option for lipoprotein lipase deficiency- Dr. Jan Albert Kuivenhoven
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60 min
26. Cardiovascular diseases: from epidemiology to nutritional interventions- Dr. Antonis Zampelas
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45 min
27. Genetic testing for CHD risk: fact or fiction?- Prof. Steve Humphries
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35 min
28. Pharmacogenetics: progress, pitfalls and clinical potential- Prof. Steve Humphries
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50 min
29. Familial hyperchlolesterolaemia: a monogenic cause of early CHD- Prof. Steve Humphries
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29 min
30. Lipid metabolism- Dr. Ulrike Beisiegel
Printable Handouts
Navigable Slide Index
- Introduction
- Cardiovascular risk and risk factors
- Different risk categories
- CVD - leading cause of adult mortality worldwide
- Leading causes of death, Canada, 1998
- CVD mortality, USA, 1980-2003
- Standardized mortality- Czech Rep., 1990-2006
- Global burden of cardiovascular disease
- The EUROASPIRE III study
- Atherogenesis
- Atherosclerosis
- Clinical manifestations of atherosclerosis
- Risk factors
- Risk factors for cardiovascular disease
- Modifiable vs. non-modifiable risk factors
- The risk is multiplicative
- Combination of risk factors increases risk of MI
- Non-modifiable risk factors
- Modifiable risk factors
- Dyslipidemia as a significant risk factor for CVD
- Structure of lipoproteins
- Classification of dyslipidaemias
- Types of lipoprotein particles
- Relationship between cholesterol and CHD risk
- Relationship of serum cholesterol to mortality
- LDL cholesterol
- Relationship between LDL-C and CV event rate
- Prevalence of raised LDL cholesterol
- HDL cholesterol
- Triglycerides
- Triglyceride levels and LDL phenotypes
- Impact of TG levels on relative risk (RR) of CHD
- Apolipoproteins
- The INTERHEART study
- Risk of AMI associated with risk factors
- Risk factors and risk of MI
- ApoB/ApoA-I as a predictor of risk
- INTERHEART study conclusion
- Indicators of plasma atherogenic phenotype
- CAD risk and HDL particle size
- HDL protective and risk particles
- CAD risk and LDL particle size
- Subfrakce LDL
- CAD risk and VLDL particle size
- TG and HDL-C levels determine LP particle size
- Smoking as a risk factor for CVD
- Smoking and mortality
- Cumulative tobacco related death rate worldwide
- Smoking and MI risk
- CHD risk and smoking: dose dependence
- Passive smoking risk
- Smoking and atherogenesis
- Adverse effect of smoking on different risk factors
- Endothelium damage after smoke exposure
- Prevalence of smoking
- Diabetes as a risk factor for CVD
- Diabetes mellitus
- Estimates of incident of type II diabetes
- Types of diabetes mellitus
- The chronic complications of diabetes mellitus
- Typical lipid profile in patients with/without DM
- Diabetics at similar risk to non diabetics with CVD
- Less favourable angioplasty outcome in diabetes
- Diabetic resistance to CVD preventive strategies
- Prevalence of diabetes
- The metabolic syndrome
- The MetS and associated CVD risk factors
- Criteria for diagnosis of the metabolic syndrome
- Prevalence of MetS in the USA
- MetS and CVD
- Higher rates of atherosclerosis in MetS patients
- Overweight and obesity as a risk factor
- Prevalence of obesity
- Survival of the fittest
- How to assess the risk?
- Risk assessment
- Why do we assess risk?
- The SCORE chart
- Framingham point score
- Atherosclerosis imaging (1)
- Atherosclerosis imaging (2)
- Intima media thickness (IMT)
- IMT and CV events
- Carotid IMT measurement
- IMT of carotid arteries
- Normal finding on carotid US
- Pathological finding
- Carotid IMT is a measure of atherosclerosis
- Example of atherosclerosis regression, IVUS
- CT angiography
- Conclusions
Topics Covered
- Cardiovascular disease burden
- Atherosclerosis as a cause of CVD
- Non-modifiable and modifiable risk factors for CVD
- Dyslipidemia and CVD risk
- Apoproteins as CVD risk predictors
- Quality of lipoprotein particles as an important indicator of lipids associated risk
- Smoking as a CVD risk factor
- Diabetes as a risk factor for CVD
- Metabolic syndrome and CVD risk
- Risk assessment tools
- Atherosclerosis imaging techniques and risk assessment
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Vrablik, M. (2008, November 24). Cardiovascular risk factors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/JUMX6928.Export Citation (RIS)
Publication History
- Published on November 24, 2008
Financial Disclosures
- Dr. Michal Vrablik has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Cardiovascular risk factors
Published on November 24, 2008
44 min
