• The Notion of Epigenetics
• 43 min
  1. Cytoplasmic epigenetics: inheritance by cytoplasmic continuity

  • Prof. Philippe Silar
  • Dr. Fabienne Malagnac
• Epigenetics: Paradigms
• 38 min
  2. The molecular mechanism of X chromosome inactivation

  • Prof. Neil Brockdorff
• 29 min
  3. Genomic imprinting: history and embryology

  • Prof. Davor Solter
• 48 min
  4. X chromosome inactivation in human cells

  • Prof. Barbara Migeon
• 41 min
  5. RNAi and heterochromatin in plants and fission yeast

  • Prof. Robert Martienssen
• Epigenetics: Mechanisms
• 23 min
  6. Polycomb epigenetic mechanisms: role of PcG complexes

  • Prof. Vincenzo Pirrotta
• 29 min
  7. Polycomb epigenetic mechanisms: methylation of DNA

  • Prof. Vincenzo Pirrotta
• 56 min
  8. Histone modifications and prospects for an epigenetic code

  • Prof. Bryan Turner
• 68 min
  9. Epigenetic control by histone methylation

  • Prof. Thomas Jenuwein
• 38 min
  10. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 51 min
  11. Gene silencing in budding yeast

  • Prof. Susan Gasser
• Epigenetics: Heritability and Reversibility
• 51 min
  12. Nuclear cloning, stem cells and epigenetic reprogramming

  • Prof. Rudolf Jaenisch
• 64 min
  13. Stem cell memory

  • Prof. James Sherley
• Archived Lectures *These may not cover the latest advances in the field
• 24 min
  14. Epigenetics: a historical overview

  • Dr. Robin Holliday
• 43 min
  15. DNA methylation

  • Prof. Adrian Bird
• 45 min
  16. DNA methylation and genome defense in Neurospora crassa

  • Prof. Eric Selker
• 34 min
  17. A historical perspective on ideas on X-chromosome inactivation

  • Dr. Mary Lyon
• 40 min
  18. Evolution of mammal epigenetic control systems

  • Prof. Jenny Graves
• 60 min
  19. Genomic imprinting and its regulation

  • Dr. Anne Ferguson-Smith
• 40 min
  20. Nuclear organization and gene expression

  • Prof. David Spector
• 39 min
  21. Germ cells

  • Prof. Azim Surani
• 41 min
  22. Epigenetic regulation of phenotype

  • Prof. Emma Whitelaw
• 68 min
  23. Epigenetically mediated gene silencing: a companion to genetic alterations in driving tumorigenesis

  • Prof. Stephen Baylin
• 36 min
  24. Cytoplasmic epigenetics: proteins acting as genes

  • Prof. Reed Wickner

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Definition of 'epigenetics'
3. Non-chromosomal components of yeast genome
4. Inheritance vs. infection
5. Prions: definition and classification
6. [URE3] and [PSI] as prions
7. Genetic criteria for a prion: illustrated with [URE3]
8. Prion domain of Ure2p
9. Comparison of prion domains
10. Amyloid: a pathogenic protein form
11. Amyloid of Ure2p is the basis of the [URE3] prion
12. Ure2p filaments are present only in [URE3] cells
13. Architecture of Ure2p amyloid filaments
14. Ure2p C-terminal domain
15. Shuffling of Ure2 prion domain
16. Sequence independence of prion domain
17. In-register structure explains prion properties
18. Amyloid assembly by Ure2p
19. Ure2 from pathogenic yeasts
20. Chaperones and prions
21. Prion variants and species barrier
22. Prion strain affects species barrier
23. Infection with prions by introduction of amyloid
24. Heterokaryon incompatibility
25. [Het-s] and meiotic drive
26. Yeast prions: help or hindrance
27. Selfish RNAs, DNAs and prions
28. Major challenges for prion research
29. References (1)
30. References (2)

Topics Covered

• Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae
• these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions
• the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility

Links

Series:

• Epigenetics

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Reed Wickner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.