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1. Introduction
2. Global stroke burden
3. Thromboembolic occlusions and ischemic damage
4. Possible interventions
5. Consequences of low blood flow
6. Recanalisation is associated with improvement
7. Time is brain
8. Where do thromboembolic occlusions originate?
9. How can recanalisation be achieved?
10. Pharmacological treatment
11. Pharmacological treatment: alteplase
12. Outcomes of alteplase treatment vs. placebo
13. Importance of delay from stroke onset to treatment
14. SITS-MOST
15. Thrombolysis is safe and effective
16. SITS-MOST univariate analysis results
17. Door to needle time
18. Treatment indications for intravenous rt-PA
19. Comments on usual misunderstandings
20. Treatment beyond European labelling
21. Concern for haemorrhagic complications
22. Risk factors for intracerebral haemorrhage (1)
23. Risk factors for intracerebral haemorrhage (2)
24. Recanalisation intervention beyond 3 hours
25. Recanalisation strategies beyond i.v. thrombolysis
26. HMCAS disappearance after i.v. thrombolysis
27. HMCAS disappearance is important to outcome
28. Thrombectomy using the MERCI device
29. Example for the use of MERCI: background
30. Example for the use of MERCI: the occlusion
31. Example for the use of MERCI: the device location
32. Example for the use of MERCI: recanalisation
33. A clot on the MERCI device
34. Combined iv thrombolysis- thrombectomy strategy
35. Sonothrombolysis
36. Possible hemorrhage and oedema complications
37. Oedema complication
38. Decompressive surgery
39. Functional outcomes of decompressive surgery
40. Risk reduction and odds ratio following surgery
41. Eligibility criteria for the pooled analysis
42. Exclusion criteria
43. Thrombolysis for intracerebral haemorrhage
44. New standards for organised stroke care
45. Summary
46. Thank you for your attention

Topics Covered

• Global stroke burden
• Neurological symptoms
• Where do thromboembolic occlusions originate?
• Recanalization
• Pharmacological treatment
• Clinical trials
• Treatment indications for intravenous rt-PA
• Common misunderstandings
• Treatment recommendations
• Haemorrhagic complications in routine clinical practice
• Multivariate analysis
• Risk factors
• Intravenous thrombolysis
• SITS
• Pooled analysis
• Thrombolysis and highly specialized interventions require new standards for organized stroke care

Links

Series:

• Cerebrovascular Disease

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Wahlgren, N. (2008, October 27). The treatment of stroke: specific management - thrombolysis plus [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/NAFG2782.
Export Citation (RIS)

Publication History

• Published on October 27, 2008
• Archived on December 10, 2018

Financial Disclosures

• Prof. Nils Wahlgren has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.